FUNDC1 (FUN14 domain containing 1)

2017-01-01  

Identity

HGNC
FUNDC1
LOCATION
Xp11.3
LOCUSID
139341

Other Information

Locus ID:

NCBI: 139341
MIM: 300871
HGNC: 28746
Ensembl: ENSG00000069509

Variants:

dbSNP: 139341
ClinVar: 139341
TCGA: ENSG00000069509
COSMIC: FUNDC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000069509ENST00000378045Q8IVP5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
222670862012Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells.348
246710352014ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy.118
270504582016Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy.57
271459332016FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact site under hypoxic conditions.55
251267232014The BCL2L1 and PGAM5 axis defines hypoxia-induced receptor-mediated mitophagy.39
281047342017Mitochondrial E3 ligase MARCH5 regulates FUNDC1 to fine-tune hypoxic mitophagy.35
277578472017Structural insights into the recognition of phosphorylated FUNDC1 by LC3B in mitophagy.21
276532722016Structural basis for the phosphorylation of FUNDC1 LIR as a molecular switch of mitophagy.15
300533282019FUN14 Domain-Containing 1-Mediated Mitophagy Suppresses Hepatocarcinogenesis by Inhibition of Inflammasome Activation in Mice.15
287191482017High expression of FUNDC1 predicts poor prognostic outcomes and is a promising target to improve chemoradiotherapy effects in patients with cervical cancer.6

Citation

Dessen P

FUNDC1 (FUN14 domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2017-01-01

Online version: http://atlasgeneticsoncology.org/gene/56706/fundc1-(fun14-domain-containing-1)