MX2 (MX dynamin like GTPase 2)

2017-04-01  

Identity

HGNC
LOCATION
21q22.3
LOCUSID
ALIAS
MXB
FUSION GENES

Other Information

Locus ID:

NCBI: 4600
MIM: 147890
HGNC: 7533
Ensembl: ENSG00000183486

Variants:

dbSNP: 4600
ClinVar: 4600
TCGA: ENSG00000183486
COSMIC: MX2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183486ENST00000330714P20592
ENSG00000183486ENST00000416447C9J9T4
ENSG00000183486ENST00000418103C9JEL4
ENSG00000183486ENST00000435611C9JS04
ENSG00000183486ENST00000436410C9JZQ9

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733
Antiviral mechanism by IFN-stimulated genesREACTOMER-HSA-1169410
ISG15 antiviral mechanismREACTOMER-HSA-1169408

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
367433062023Polymorphisms of the MxA and MxB genes are associated with biochemical indices and viral subtypes in Yunnan HCV patients.0
377961302023A single polymorphic residue in humans underlies species-specific restriction of HSV-1 by the antiviral protein MxB.0
367433062023Polymorphisms of the MxA and MxB genes are associated with biochemical indices and viral subtypes in Yunnan HCV patients.0
377961302023A single polymorphic residue in humans underlies species-specific restriction of HSV-1 by the antiviral protein MxB.0
355056822022Genetic polymorphisms in the IFNL4, MxA, and MxB genes were associated with biochemical index of chronic HBV patients from Yunnan, China.3
360595472022MX2: Identification and systematic mechanistic analysis of a novel immune-related biomarker for systemic lupus erythematosus.8
355056822022Genetic polymorphisms in the IFNL4, MxA, and MxB genes were associated with biochemical index of chronic HBV patients from Yunnan, China.3
360595472022MX2: Identification and systematic mechanistic analysis of a novel immune-related biomarker for systemic lupus erythematosus.8
337345792021MX2 mediates establishment of interferon response profile, regulates XAF1, and can sensitize melanoma cells to targeted therapy.3
339331702021The transcriptome profile of human trisomy 21 blood cells.11
342823092021MX2-mediated innate immunity against HIV-1 is regulated by serine phosphorylation.13
347071742021High accumulation of Mx2 renders limited multiplication of oncolytic herpes simplex virus-1 in human tumor cells.2
337345792021MX2 mediates establishment of interferon response profile, regulates XAF1, and can sensitize melanoma cells to targeted therapy.3
339331702021The transcriptome profile of human trisomy 21 blood cells.11
342823092021MX2-mediated innate immunity against HIV-1 is regulated by serine phosphorylation.13

Citation

Dessen P

MX2 (MX dynamin like GTPase 2)

Atlas Genet Cytogenet Oncol Haematol. 2017-04-01

Online version: http://atlasgeneticsoncology.org/gene/56797/gene-fusions/css/lib/dataTables.bootstrap.min.css