CFP (complement factor properdin)

2017-08-01  

Identity

HGNC
CFP
LOCATION
Xp11.23
LOCUSID
5199
ALIAS
BFD,PFC,PFD,PROPERDIN
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5199
MIM: 300383
HGNC: 8864
Ensembl: ENSG00000126759

Variants:

dbSNP: 5199
ClinVar: 5199
TCGA: ENSG00000126759
COSMIC: CFP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000126759ENST00000247153P27918
ENSG00000126759ENST00000247153A0A0S2Z4I5
ENSG00000126759ENST00000377005E9PAQ1
ENSG00000126759ENST00000396992P27918
ENSG00000126759ENST00000396992A0A0S2Z4I5
ENSG00000126759ENST00000469388C9J7V5

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
O-linked glycosylationREACTOMER-HSA-5173105
O-glycosylation of TSR domain-containing proteinsREACTOMER-HSA-5173214
DiseaseREACTOMER-HSA-1643685
Diseases of glycosylationREACTOMER-HSA-3781865
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Diseases associated with O-glycosylation of proteinsREACTOMER-HSA-3906995
Defective B3GALTL causes Peters-plus syndrome (PpS)REACTOMER-HSA-5083635
Neutrophil degranulationREACTOMER-HSA-6798695

References

Pubmed IDYearTitleCitations
350316112022Structure and function of a family of tick-derived complement inhibitors targeting properdin.6
358430302022Properdin produced by dendritic cells contributes to the activation of T cells.2
350316112022Structure and function of a family of tick-derived complement inhibitors targeting properdin.6
358430302022Properdin produced by dendritic cells contributes to the activation of T cells.2
334941382021Properdin Is a Modulator of Tumour Immunity in a Syngeneic Mouse Melanoma Model.2
334941382021Properdin Is a Modulator of Tumour Immunity in a Syngeneic Mouse Melanoma Model.2
327932012020Properdin Is a Key Player in Lysis of Red Blood Cells and Complement Activation on Endothelial Cells in Hemolytic Anemias Caused by Complement Dysregulation.8
329099422020Soluble collectin-12 mediates C3-independent docking of properdin that activates the alternative pathway of complement.10
332402632020The Role of Properdin in Killing of Non-Pathogenic Leptospira biflexa.1
327932012020Properdin Is a Key Player in Lysis of Red Blood Cells and Complement Activation on Endothelial Cells in Hemolytic Anemias Caused by Complement Dysregulation.8
329099422020Soluble collectin-12 mediates C3-independent docking of properdin that activates the alternative pathway of complement.10
332402632020The Role of Properdin in Killing of Non-Pathogenic Leptospira biflexa.1
307557302019CFP suppresses breast cancer cell growth by TES-mediated upregulation of the transcription factor DDIT3.16
307557302019CFP suppresses breast cancer cell growth by TES-mediated upregulation of the transcription factor DDIT3.16
287843232018Polymorphisms in genes related to the complement system and antibody-mediated cardiac allograft rejection.7

Citation

Dessen P

CFP (complement factor properdin)

Atlas Genet Cytogenet Oncol Haematol. 2017-08-01

Online version: http://atlasgeneticsoncology.org/gene/56951/haematological-explorer/js/_common.js