SLC13A2 (solute carrier family 13 member 2)

2017-08-01  

Identity

HGNC
LOCATION
17q11.2
LOCUSID
ALIAS
NADC1,NaCT,NaDC-1,SDCT1
FUSION GENES

Other Information

Locus ID:

NCBI: 9058
MIM: 604148
HGNC: 10917
Ensembl: ENSG00000007216

Variants:

dbSNP: 9058
ClinVar: 9058
TCGA: ENSG00000007216
COSMIC: SLC13A2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000007216ENST00000314669Q13183
ENSG00000007216ENST00000444914Q13183
ENSG00000007216ENST00000459818J3QR70
ENSG00000007216ENST00000545060F5GWV6
ENSG00000007216ENST00000577903J3QLA5
ENSG00000007216ENST00000579281J3QR70

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Sodium-coupled sulphate, di- and tri-carboxylate transportersREACTOMER-HSA-433137

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
124458242002Human Na+ -coupled citrate transporter: primary structure, genomic organization, and transport function.39
157744652005Conformationally sensitive residues in extracellular loop 5 of the Na+/dicarboxylate co-transporter.18
174701692007Associations between renal sodium-citrate cotransporter (hNaDC-1) gene polymorphism and urinary citrate excretion in recurrent renal calcium stone formers and normal controls.12
174701692007Associations between renal sodium-citrate cotransporter (hNaDC-1) gene polymorphism and urinary citrate excretion in recurrent renal calcium stone formers and normal controls.12
206105292010Single nucleotide polymorphisms in the human Na+-dicarboxylate cotransporter affect transport activity and protein expression.8
212577492011Synthesis, maturation, and trafficking of human Na+-dicarboxylate cotransporter NaDC1 requires the chaperone activity of cyclophilin B.6
181619882008Threonine-509 is a determinant of apparent affinity for both substrate and cations in the human Na+/dicarboxylate cotransporter.4
279276542017Expression of sodium-dependent dicarboxylate transporter 1 (NaDC1/SLC13A2) in normal and neoplastic human kidney.4
287313302017Mapping Functionally Important Residues in the Na+/Dicarboxylate Cotransporter, NaDC1.2
156201092004Expression of EGFP/SDCT1 fusion protein, subcellular localization signal analysis, tissue distribution and electrophysiological function study.0

Citation

Dessen P

SLC13A2 (solute carrier family 13 member 2)

Atlas Genet Cytogenet Oncol Haematol. 2017-08-01

Online version: http://atlasgeneticsoncology.org/gene/57003/slc13a2-(solute-carrier-family-13-member-2)