LGR6 (leucine rich repeat containing G protein-coupled receptor 6)

2017-08-01  

Identity

HGNC
LGR6
LOCATION
1q32.1
LOCUSID
59352
ALIAS
GPCR,VTS20631
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 59352
MIM: 606653
HGNC: 19719
Ensembl: ENSG00000133067

Variants:

dbSNP: 59352
ClinVar: 59352
TCGA: ENSG00000133067
COSMIC: LGR6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133067ENST00000255432Q9HBX8
ENSG00000133067ENST00000367278Q9HBX8
ENSG00000133067ENST00000423542Q5T508
ENSG00000133067ENST00000439764Q9HBX8
ENSG00000133067ENST00000487787D6R9F0

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Regulation of FZD by ubiquitinationREACTOMER-HSA-4641263

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
380144542024The oncogenic role of LGR6 overexpression induced by aberrant Wnt/β-catenin signaling in lung cancer.1
380144542024The oncogenic role of LGR6 overexpression induced by aberrant Wnt/β-catenin signaling in lung cancer.1
377702302023WNT enhancing signals in pancreatic cancer are transmitted by LGR6.0
378027072023DNA methylation and expression of LGR6 gene in ankylosing spondylitis: A case-control study.0
377702302023WNT enhancing signals in pancreatic cancer are transmitted by LGR6.0
378027072023DNA methylation and expression of LGR6 gene in ankylosing spondylitis: A case-control study.0
344895512021LGR6 activates the Wnt/β-catenin signaling pathway and forms a β-catenin/TCF7L2/LGR6 feedback loop in LGR6(high) cervical cancer stem cells.8
344945322021[Expression and Significance of Leucine-rich Repeat-containing G-protein Coupled Receptor 5/6 in Wnt Pathway in Children with Acute Lymphoblastic Leukemia].0
349439452021Increased LGR6 Expression Sustains Long-Term Wnt Activation and Acquisition of Senescence in Epithelial Progenitors in Chronic Lung Diseases.4
344895512021LGR6 activates the Wnt/β-catenin signaling pathway and forms a β-catenin/TCF7L2/LGR6 feedback loop in LGR6(high) cervical cancer stem cells.8
344945322021[Expression and Significance of Leucine-rich Repeat-containing G-protein Coupled Receptor 5/6 in Wnt Pathway in Children with Acute Lymphoblastic Leukemia].0
349439452021Increased LGR6 Expression Sustains Long-Term Wnt Activation and Acquisition of Senescence in Epithelial Progenitors in Chronic Lung Diseases.4
319178822020LGR6 is a potential diagnostic and prognostic marker for esophageal squamous cell carcinoma.6
322441722020Epithelial stem cell marker LGR6 expression identifies a low-risk subgroup in human papillomavirus positive oropharyngeal squamous cell carcinoma.2
331095402020WNT Signaling Driven by R-spondin 1 and LGR6 in High-grade Serous Ovarian Cancer.4

Citation

Dessen P

LGR6 (leucine rich repeat containing G protein-coupled receptor 6)

Atlas Genet Cytogenet Oncol Haematol. 2017-08-01

Online version: http://atlasgeneticsoncology.org/gene/57032/gene-explorer/css/meetings