N6AMT1 (N-6 adenine-specific DNA methyltransferase 1)

2017-10-01  

Identity

HGNC
N6AMT1
LOCATION
21q21.3
LOCUSID
29104
ALIAS
C21orf127,HEMK2,KMT9,MTQ2,N6AMT,PRED28,PrmC,m.HsaHemK2P

Other Information

Locus ID:

NCBI: 29104
MIM: 614553
HGNC: 16021
Ensembl: ENSG00000156239

Variants:

dbSNP: 29104
ClinVar: 29104
TCGA: ENSG00000156239
COSMIC: N6AMT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000156239ENST00000303775Q9Y5N5
ENSG00000156239ENST00000351429Q9Y5N5
ENSG00000156239ENST00000460212Q9Y5N5

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation TerminationREACTOMER-HSA-72764
Gene ExpressionREACTOMER-HSA-74160
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
MethylationREACTOMER-HSA-156581

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA166129560major adverse cardiac events (mace)DiseaseClinicalAnnotationassociatedPKPD
PA449053clopidogrelChemicalClinicalAnnotationassociatedPKPD

References

Pubmed IDYearTitleCitations
382844882024Distinct specificities of the HEMK2 protein methyltransferase in methylation of glutamine and lysine residues.0
382844882024Distinct specificities of the HEMK2 protein methyltransferase in methylation of glutamine and lysine residues.0
366811422023Arsenic metabolism, N6AMT1 and AS3MT single nucleotide polymorphisms, and their interaction on gestational diabetes mellitus in Chinese pregnant women.3
366811422023Arsenic metabolism, N6AMT1 and AS3MT single nucleotide polymorphisms, and their interaction on gestational diabetes mellitus in Chinese pregnant women.3
347372132022KMT9 Controls Stemness and Growth of Colorectal Cancer.15
352565952022Reducing N6AMT1-mediated 6mA DNA modification promotes breast tumor progression via transcriptional repressing cell cycle inhibitors.10
347372132022KMT9 Controls Stemness and Growth of Colorectal Cancer.15
352565952022Reducing N6AMT1-mediated 6mA DNA modification promotes breast tumor progression via transcriptional repressing cell cycle inhibitors.10
329694632020Structural insight into HEMK2-TRMT112-mediated glutamine methylation.6
329694632020Structural insight into HEMK2-TRMT112-mediated glutamine methylation.6
310615262019KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells.39
314663822019The Common Partner of Several Methyltransferases TRMT112 Regulates the Expression of N6AMT1 Isoforms in Mammalian Cells.9
310615262019KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells.39
314663822019The Common Partner of Several Methyltransferases TRMT112 Regulates the Expression of N6AMT1 Isoforms in Mammalian Cells.9
300175832018N(6)-Methyladenine DNA Modification in the Human Genome.221

Citation

Dessen P

N6AMT1 (N-6 adenine-specific DNA methyltransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57077/deep-insight-explorer/js/lib/bootstrap.min.js