TAS2R8 (taste 2 receptor member 8)

2017-10-01  

Identity

HGNC
TAS2R8
LOCATION
12p13.2
LOCUSID
50836
ALIAS
T2R8,TRB5

Other Information

Locus ID:

NCBI: 50836
MIM: 604794
HGNC: 14915
Ensembl: ENSG00000121314

Variants:

dbSNP: 50836
ClinVar: 50836
TCGA: ENSG00000121314
COSMIC: TAS2R8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000121314ENST00000240615Q9NYW2

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Taste transductionKEGGko04742
Taste transductionKEGGhsa04742
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class C/3 (Metabotropic glutamate/pheromone receptors)REACTOMER-HSA-420499
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

References

Pubmed IDYearTitleCitations
330712572020Intracellular zinc-dependent TAS2R8 gene expression through CTCF activation.1
330712572020Intracellular zinc-dependent TAS2R8 gene expression through CTCF activation.1
284675172017Anti-cancer stemness and anti-invasive activity of bitter taste receptors, TAS2R8 and TAS2R10, in human neuroblastoma cells.18
284675172017Anti-cancer stemness and anti-invasive activity of bitter taste receptors, TAS2R8 and TAS2R10, in human neuroblastoma cells.18
216705122011Human bitter taste receptors hTAS2R8 and hTAS2R39 with differential functions to recognize bitter peptides.5
216705122011Human bitter taste receptors hTAS2R8 and hTAS2R39 with differential functions to recognize bitter peptides.5

Citation

Dessen P

TAS2R8 (taste 2 receptor member 8)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57103/favicon/js/web-card-_common.js