JCAD (junctional cadherin 5 associated)

2017-10-01  

Identity

HGNC
JCAD
LOCATION
10p11.23
LOCUSID
57608
ALIAS
KIAA1462

Other Information

Locus ID:

NCBI: 57608
MIM: 614398
HGNC: 29283
Ensembl: ENSG00000165757

Variants:

dbSNP: 57608
ClinVar: 57608
TCGA: ENSG00000165757
COSMIC: JCAD

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000165757ENST00000375377Q9P266

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381908292024JCAD deficiency attenuates activation of hepatic stellate cells and cholestatic fibrosis.4
381908292024JCAD deficiency attenuates activation of hepatic stellate cells and cholestatic fibrosis.4
364694882023JCAD promotes arterial thrombosis through PI3K/Akt modulation: a translational study.10
364694882023JCAD promotes arterial thrombosis through PI3K/Akt modulation: a translational study.10
315840652020A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction.17
315840652020A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction.17
315399142019The novel coronary artery disease risk gene JCAD/KIAA1462 promotes endothelial dysfunction and atherosclerosis.40
315399142019The novel coronary artery disease risk gene JCAD/KIAA1462 promotes endothelial dysfunction and atherosclerosis.40
297941142018JCAD, a Gene at the 10p11 Coronary Artery Disease Locus, Regulates Hippo Signaling in Endothelial Cells.31
297941142018JCAD, a Gene at the 10p11 Coronary Artery Disease Locus, Regulates Hippo Signaling in Endothelial Cells.31
287057942017Targeted Disruption of JCAD (Junctional Protein Associated With Coronary Artery Disease)/KIAA1462, a Coronary Artery Disease-Associated Gene Product, Inhibits Angiogenic Processes In Vitro and In Vivo.17
287751682017JCAD Promotes Progression of Nonalcoholic Steatohepatitis to Liver Cancer by Inhibiting LATS2 Kinase Activity.40
287057942017Targeted Disruption of JCAD (Junctional Protein Associated With Coronary Artery Disease)/KIAA1462, a Coronary Artery Disease-Associated Gene Product, Inhibits Angiogenic Processes In Vitro and In Vivo.17
287751682017JCAD Promotes Progression of Nonalcoholic Steatohepatitis to Liver Cancer by Inhibiting LATS2 Kinase Activity.40
243492192013KIAA1462, a coronary artery disease associated gene, is a candidate gene for late onset Alzheimer disease in APOE carriers.7

Citation

Dessen P

JCAD (junctional cadherin 5 associated)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57115/cancer-prone-explorer/js/_common.js