EIF5B (eukaryotic translation initiation factor 5B)

2018-02-01  

Identity

HGNC
EIF5B
LOCATION
2q11.2
LOCUSID
9669
ALIAS
IF2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9669
MIM: 606086
HGNC: 30793
Ensembl: ENSG00000158417

Variants:

dbSNP: 9669
ClinVar: 9669
TCGA: ENSG00000158417
COSMIC: EIF5B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000158417ENST00000289371O60841
ENSG00000158417ENST00000617677A0A087WUT6

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA transportKEGGko03013
RNA transportKEGGhsa03013
Metabolism of proteinsREACTOMER-HSA-392499
TranslationREACTOMER-HSA-72766
Eukaryotic Translation InitiationREACTOMER-HSA-72613
Cap-dependent Translation InitiationREACTOMER-HSA-72737
GTP hydrolysis and joining of the 60S ribosomal subunitREACTOMER-HSA-72706
Gene ExpressionREACTOMER-HSA-74160

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
349233942022Dynamic interaction network involving the conserved intrinsically disordered regions in human eIF5.2
357327352022eIF5B and eIF1A reorient initiator tRNA to allow ribosomal subunit joining.19
349233942022Dynamic interaction network involving the conserved intrinsically disordered regions in human eIF5.2
357327352022eIF5B and eIF1A reorient initiator tRNA to allow ribosomal subunit joining.19
331239152021Depletion of eukaryotic initiation factor 5B (eIF5B) reprograms the cellular transcriptome and leads to activation of endoplasmic reticulum (ER) stress and c-Jun N-terminal kinase (JNK).4
345259512021eIF5B regulates the expression of PD-L1 in prostate cancer cells by interacting with Wig1.3
331239152021Depletion of eukaryotic initiation factor 5B (eIF5B) reprograms the cellular transcriptome and leads to activation of endoplasmic reticulum (ER) stress and c-Jun N-terminal kinase (JNK).4
345259512021eIF5B regulates the expression of PD-L1 in prostate cancer cells by interacting with Wig1.3
316712792020Eukaryotic initiation factor 5B (eIF5B) regulates temozolomide-mediated apoptosis in brain tumour stem cells (BTSCs).3
329848442020eIF5B drives integrated stress response-dependent translation of PD-L1 in lung cancer.46
316712792020Eukaryotic initiation factor 5B (eIF5B) regulates temozolomide-mediated apoptosis in brain tumour stem cells (BTSCs).3
329848442020eIF5B drives integrated stress response-dependent translation of PD-L1 in lung cancer.46
306706982019Eukaryotic initiation factor 5B (eIF5B) provides a critical cell survival switch to glioblastoma cells via regulation of apoptosis.16
306706982019Eukaryotic initiation factor 5B (eIF5B) provides a critical cell survival switch to glioblastoma cells via regulation of apoptosis.16
292984192018Oxygen-Sensitive Remodeling of Central Carbon Metabolism by Archaic eIF5B.22

Citation

Dessen P

EIF5B (eukaryotic translation initiation factor 5B)

Atlas Genet Cytogenet Oncol Haematol. 2018-02-01

Online version: http://atlasgeneticsoncology.org/gene/57365/cancer-prone-explorer/deep-insight-explorer/js/lib/all.min.js