CLEC2D (C-type lectin domain family 2 member D)

2018-07-01  

Identity

HGNC
CLEC2D
LOCATION
12p13.31
LOCUSID
29121
ALIAS
CLAX,LLT1,OCIL
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 29121
MIM: 605659
HGNC: 14351
Ensembl: ENSG00000069493

Variants:

dbSNP: 29121
ClinVar: 29121
TCGA: ENSG00000069493
COSMIC: CLEC2D

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000069493ENST00000261339Q9UHP7
ENSG00000069493ENST00000261339W8JXM2
ENSG00000069493ENST00000261340Q9UHP7
ENSG00000069493ENST00000290855Q9UHP7
ENSG00000069493ENST00000325960F8WF99
ENSG00000069493ENST00000430909A0A0C4DG81
ENSG00000069493ENST00000444971F8WF99
ENSG00000069493ENST00000460309H0YGG6
ENSG00000069493ENST00000466035H0YH49
ENSG00000069493ENST00000476198F5H0P0
ENSG00000069493ENST00000479877Q9UHP7
ENSG00000069493ENST00000492359F5H5U4
ENSG00000069493ENST00000536355F5H0P0
ENSG00000069493ENST00000543300Q9UHP7
ENSG00000069493ENST00000544322A0A0C4DGG4
ENSG00000069493ENST00000545918Q9UHP7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
385020582024Immune checkpoint CD161/LLT1-associated immunological landscape and diagnostic value in oral squamous cell carcinoma.1
386739022024Lectin-like Transcript-1 (LLT1) Expression in Oral Squamous Cell Carcinomas: Prognostic Significance and Relationship with the Tumor Immune Microenvironment.0
385020582024Immune checkpoint CD161/LLT1-associated immunological landscape and diagnostic value in oral squamous cell carcinoma.1
386739022024Lectin-like Transcript-1 (LLT1) Expression in Oral Squamous Cell Carcinomas: Prognostic Significance and Relationship with the Tumor Immune Microenvironment.0
372879722023SARS-CoV-2 infection impairs NK cell functions via activation of the LLT1-CD161 axis.9
372879722023SARS-CoV-2 infection impairs NK cell functions via activation of the LLT1-CD161 axis.9
351859352022LLT1-CD161 Interaction in Cancer: Promises and Challenges.18
351859352022LLT1-CD161 Interaction in Cancer: Promises and Challenges.18
318590492020Immune Sensing of Cell Death through Recognition of Histone Sequences by C-Type Lectin-Receptor-2d Causes Inflammation and Tissue Injury.33
324498112020Docetaxel suppresses immunotherapy efficacy of natural killer cells toward castration-resistant prostate cancer cells via altering androgen receptor-lectin-like transcript 1 signals.5
332885562020Role of LLT1 and PCNA as Natural Killer Cell Immune Evasion Strategies of HCT 116 Cells.8
318590492020Immune Sensing of Cell Death through Recognition of Histone Sequences by C-Type Lectin-Receptor-2d Causes Inflammation and Tissue Injury.33
324498112020Docetaxel suppresses immunotherapy efficacy of natural killer cells toward castration-resistant prostate cancer cells via altering androgen receptor-lectin-like transcript 1 signals.5
332885562020Role of LLT1 and PCNA as Natural Killer Cell Immune Evasion Strategies of HCT 116 Cells.8
309550822019Lectin-like transcript 1 (LLT1) expression is associated with nodal metastasis in patients with head and neck cutaneous squamous cell carcinoma.7

Citation

Dessen P

CLEC2D (C-type lectin domain family 2 member D)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57404/favicon/favicon/favicon-16x16.png