CLEC6A (C-type lectin domain containing 6A)

2018-07-01  

Identity

HGNC
CLEC6A
LOCATION
12p13.31
LOCUSID
93978
ALIAS
CLEC4N,CLECSF10,dectin-2,hDECTIN-2

Other Information

Locus ID:

NCBI: 93978
MIM: 613579
HGNC: 14556
Ensembl: ENSG00000205846

Variants:

dbSNP: 93978
ClinVar: 93978
TCGA: ENSG00000205846
COSMIC: CLEC6A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000205846ENST00000382073Q6EIG7

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
C-type lectin receptors (CLRs)REACTOMER-HSA-5621481
Dectin-2 familyREACTOMER-HSA-5621480

References

Pubmed IDYearTitleCitations
378139652023The ligation between ERMAP, galectin-9 and dectin-2 promotes Kupffer cell phagocytosis and antitumor immunity.5
378139652023The ligation between ERMAP, galectin-9 and dectin-2 promotes Kupffer cell phagocytosis and antitumor immunity.5
360780842022SOCS3 Regulates Dectin-2-Induced Inflammation in PBMCs of Diabetic Patients.5
360780842022SOCS3 Regulates Dectin-2-Induced Inflammation in PBMCs of Diabetic Patients.5
318680002020Deletion of haematopoietic Dectin-2 or CARD9 does not protect from atherosclerosis development under hyperglycaemic conditions.4
318680002020Deletion of haematopoietic Dectin-2 or CARD9 does not protect from atherosclerosis development under hyperglycaemic conditions.4
313717672019Human thioredoxin, a damage-associated molecular pattern and Malassezia-crossreactive autoallergen, modulates immune responses via the C-type lectin receptors Dectin-1 and Dectin-2.15
313717672019Human thioredoxin, a damage-associated molecular pattern and Malassezia-crossreactive autoallergen, modulates immune responses via the C-type lectin receptors Dectin-1 and Dectin-2.15
296160192018The Syk-Coupled C-Type Lectin Receptors Dectin-2 and Dectin-3 Are Involved in Paracoccidioides brasiliensis Recognition by Human Plasmacytoid Dendritic Cells.19
296687082018Dectin-1/2-induced autocrine PGE2 signaling licenses dendritic cells to prime Th2 responses.42
304430262018Deciphering the molecular basis of mycobacteria and lipoglycan recognition by the C-type lectin Dectin-2.22
296160192018The Syk-Coupled C-Type Lectin Receptors Dectin-2 and Dectin-3 Are Involved in Paracoccidioides brasiliensis Recognition by Human Plasmacytoid Dendritic Cells.19
296687082018Dectin-1/2-induced autocrine PGE2 signaling licenses dendritic cells to prime Th2 responses.42
304430262018Deciphering the molecular basis of mycobacteria and lipoglycan recognition by the C-type lectin Dectin-2.22
286524052017Mechanism of pathogen recognition by human dectin-2.42

Citation

Dessen P

CLEC6A (C-type lectin domain containing 6A)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57471/deep-insight-explorer/js/lib/bootstrap.min.js