IFI35 (interferon induced protein 35)

2018-07-01 Affiliation

Identity

HGNC

IFI35

LOCATION

17q21.31

LOCUSID

3430

ALIAS

IFP35

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3430
MIM: 600735
HGNC: 5399
Ensembl: ENSG00000068079

Variants:

dbSNP: 3430
ClinVar: 3430
TCGA: ENSG00000068079
COSMIC: IFI35

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000068079	ENST00000415816	P80217
ENSG00000068079	ENST00000438323	P80217

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Immune System	REACTOME	R-HSA-168256
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Interferon Signaling	REACTOME	R-HSA-913531
Interferon alpha/beta signaling	REACTOME	R-HSA-909733

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
34362845	2021	IFP35 family proteins promote neuroinflammation and multiple sclerosis.	10
34362845	2021	IFP35 family proteins promote neuroinflammation and multiple sclerosis.	10
32781067	2020	IFI35 as a biomolecular marker of neuroinflammation and treatment response in multiple sclerosis.	6
32781067	2020	IFI35 as a biomolecular marker of neuroinflammation and treatment response in multiple sclerosis.	6
29350881	2018	Interferon-induced protein 35 inhibits endothelial cell proliferation, migration and re-endothelialization of injured arteries by inhibiting the nuclear factor-kappa B pathway.	20
29350881	2018	Interferon-induced protein 35 inhibits endothelial cell proliferation, migration and re-endothelialization of injured arteries by inhibiting the nuclear factor-kappa B pathway.	20
28064541	2017	The role of IFI35 in lupus nephritis and related mechanisms.	11
28109979	2017	Interferon (IFN)-induced protein 35 (IFI35) negatively regulates IFN-β-phosphorylated STAT1-RIG-I-CXCL10/CCL5 axis in U373MG astrocytoma cells treated with polyinosinic-polycytidylic acid.	14
29038465	2017	NMI and IFP35 serve as proinflammatory DAMPs during cellular infection and injury.	32
28064541	2017	The role of IFI35 in lupus nephritis and related mechanisms.	11
28109979	2017	Interferon (IFN)-induced protein 35 (IFI35) negatively regulates IFN-β-phosphorylated STAT1-RIG-I-CXCL10/CCL5 axis in U373MG astrocytoma cells treated with polyinosinic-polycytidylic acid.	14
29038465	2017	NMI and IFP35 serve as proinflammatory DAMPs during cellular infection and injury.	32
27639618	2016	Interferon (IFN)-Induced Protein 35 (IFI35), a Type I Interferon-Dependent Transcript, Upregulates Inflammatory Signaling Pathways by Activating Toll-Like Receptor 3 in Human Mesangial Cells.	8
27639618	2016	Interferon (IFN)-Induced Protein 35 (IFI35), a Type I Interferon-Dependent Transcript, Upregulates Inflammatory Signaling Pathways by Activating Toll-Like Receptor 3 in Human Mesangial Cells.	8
26342464	2015	Trim21 regulates Nmi-IFI35 complex-mediated inhibition of innate antiviral response.	22

Citation

Dessen P

IFI35 (interferon induced protein 35)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57542/img/teaching-explorer/favicon/favicon-16x16.png