ADAMTS8 (ADAM metallopeptidase with thrombospondin type 1 motif 8)

2003-02-01  

Identity

HGNC
ADAMTS8
LOCATION
11q24.3
LOCUSID
11095
ALIAS
ADAM-TS8,METH2

Other Information

Locus ID:

NCBI: 11095
MIM: 605175
HGNC: 224
Ensembl: ENSG00000134917

Variants:

dbSNP: 11095
ClinVar: 11095
TCGA: ENSG00000134917
COSMIC: ADAMTS8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134917ENST00000257359Q9UP79

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
O-linked glycosylationREACTOMER-HSA-5173105
O-glycosylation of TSR domain-containing proteinsREACTOMER-HSA-5173214
DiseaseREACTOMER-HSA-1643685
Diseases of glycosylationREACTOMER-HSA-3781865
Extracellular matrix organizationREACTOMER-HSA-1474244
Degradation of the extracellular matrixREACTOMER-HSA-1474228
Diseases associated with O-glycosylation of proteinsREACTOMER-HSA-3906995
Defective B3GALTL causes Peters-plus syndrome (PpS)REACTOMER-HSA-5083635

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
380062152024HSFAS mediates fibroblast proliferation, migration, trans-differentiation and apoptosis in hypertrophic scars via interacting with ADAMTS8.0
380062152024HSFAS mediates fibroblast proliferation, migration, trans-differentiation and apoptosis in hypertrophic scars via interacting with ADAMTS8.0
363463932023The Prognostic Value of ADAMTS8 and Its Role as a Tumor Suppressor in Breast Cancer.3
375878892023ADAMTS8 inhibits glioma development in vitro and in vivo.1
363463932023The Prognostic Value of ADAMTS8 and Its Role as a Tumor Suppressor in Breast Cancer.3
375878892023ADAMTS8 inhibits glioma development in vitro and in vivo.1
351494322022ADAMTS8 inhibited lung cancer progression through suppressing VEGFA.9
351494322022ADAMTS8 inhibited lung cancer progression through suppressing VEGFA.9
346877012021Post-translational regulation and proteolytic activity of the metalloproteinase ADAMTS8.11
346877012021Post-translational regulation and proteolytic activity of the metalloproteinase ADAMTS8.11
320337512020ADAMTS8 is frequently down-regulated in colorectal cancer and functions as a tumor suppressor.8
320337512020ADAMTS8 is frequently down-regulated in colorectal cancer and functions as a tumor suppressor.8
303674602019Differential expression of secreted factors SOSTDC1 and ADAMTS8 cause profibrotic changes in linear morphoea fibroblasts.9
306550942019The role of ADAMTS genes in the end stage of hip osteoarthritis.4
303674602019Differential expression of secreted factors SOSTDC1 and ADAMTS8 cause profibrotic changes in linear morphoea fibroblasts.9

Citation

Dessen P

ADAMTS8 (ADAM metallopeptidase with thrombospondin type 1 motif 8)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/576/gene-fusions-explorer/js/lib/js/template.js