CENPI (centromere protein I)

2018-11-01  

Identity

HGNC
CENPI
LOCATION
Xq22.1
LOCUSID
2491
ALIAS
CENP-I,FSHPRH1,LRPR1

Other Information

Locus ID:

NCBI: 2491
MIM: 300065
HGNC: 3968
Ensembl: ENSG00000102384

Variants:

dbSNP: 2491
ClinVar: 2491
TCGA: ENSG00000102384
COSMIC: CENPI

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000102384ENST00000372926Q92674
ENSG00000102384ENST00000372927Q92674
ENSG00000102384ENST00000372927A0A024RCG4
ENSG00000102384ENST00000403304Q5JX01
ENSG00000102384ENST00000423383Q92674
ENSG00000102384ENST00000423383A0A024RCG4
ENSG00000102384ENST00000435570Q5JX02

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Chromosome MaintenanceREACTOMER-HSA-73886
Nucleosome assemblyREACTOMER-HSA-774815
Deposition of new CENPA-containing nucleosomes at the centromereREACTOMER-HSA-606279

References

Pubmed IDYearTitleCitations
382329152024Immune infiltration related CENPI associates with the malignant features and drug resistance of lung adenocarcinoma.0
382329152024Immune infiltration related CENPI associates with the malignant features and drug resistance of lung adenocarcinoma.0
346178582021Centromere Protein I (CENP-I) Is Upregulated in Gastric Cancer, Predicts Poor Prognosis, and Promotes Tumor Cell Proliferation and Migration.10
346178582021Centromere Protein I (CENP-I) Is Upregulated in Gastric Cancer, Predicts Poor Prognosis, and Promotes Tumor Cell Proliferation and Migration.10
319124352020Centromere protein I (CENPI) is a candidate gene for X-linked steroid sensitive nephrotic syndrome.3
319124352020Centromere protein I (CENPI) is a candidate gene for X-linked steroid sensitive nephrotic syndrome.3
299362632018CENPI is overexpressed in colorectal cancer and regulates cell migration and invasion.15
299362632018CENPI is overexpressed in colorectal cancer and regulates cell migration and invasion.15
265273982015CENP-C and CENP-I are key connecting factors for kinetochore and CENP-A assembly.34
265273982015CENP-C and CENP-I are key connecting factors for kinetochore and CENP-A assembly.34
248625742014CENP-I and Aurora B act as a molecular switch that ties RZZ/Mad1 recruitment to kinetochore attachment status.34
255251682014Detection of mutations in LRPAP1, CTSH, LEPREL1, ZNF644, SLC39A5, and SCO2 in 298 families with early-onset high myopia by exome sequencing.47
248625742014CENP-I and Aurora B act as a molecular switch that ties RZZ/Mad1 recruitment to kinetochore attachment status.34
255251682014Detection of mutations in LRPAP1, CTSH, LEPREL1, ZNF644, SLC39A5, and SCO2 in 298 families with early-onset high myopia by exome sequencing.47
218889002011Anti-CENPI autoantibodies in scleroderma patients with features of autoimmune liver diseases.5

Citation

Dessen P

CENPI (centromere protein I)

Atlas Genet Cytogenet Oncol Haematol. 2018-11-01

Online version: http://atlasgeneticsoncology.org/gene/57689/css/js/lib/all.min.js