SCN4B (sodium voltage-gated channel beta subunit 4)

2018-11-01  

Identity

HGNC
SCN4B
LOCATION
11q23.3
LOCUSID
6330
ALIAS
ATFB17,LQT10,Navbeta4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6330
MIM: 608256
HGNC: 10592
Ensembl: ENSG00000177098

Variants:

dbSNP: 6330
ClinVar: 6330
TCGA: ENSG00000177098
COSMIC: SCN4B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177098ENST00000324727Q8IWT1
ENSG00000177098ENST00000324727B0YJ93
ENSG00000177098ENST00000529878Q8IWT1

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Adrenergic signaling in cardiomyocytesKEGGhsa04261
Adrenergic signaling in cardiomyocytesKEGGko04261
Muscle contractionREACTOMER-HSA-397014
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
L1CAM interactionsREACTOMER-HSA-373760
Interaction between L1 and AnkyrinsREACTOMER-HSA-445095
Cardiac conductionREACTOMER-HSA-5576891
Phase 0 - rapid depolarisationREACTOMER-HSA-5576892

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
386785522024Anti-NSCLC role of SCN4B by negative regulation of the cGMP-PKG pathway: Integrated utilization of bioinformatics analysis and in vitro assay validation.0
386785522024Anti-NSCLC role of SCN4B by negative regulation of the cGMP-PKG pathway: Integrated utilization of bioinformatics analysis and in vitro assay validation.0
378269142023SCN4B inhibits the progression of lung adenocarcinoma and is associated with better prognosis.1
378269142023SCN4B inhibits the progression of lung adenocarcinoma and is associated with better prognosis.1
328333402021Silencing of microRNA-3175 represses cell proliferation and invasion in prostate cancer by targeting the potential tumor-suppressor SCN4B.4
342096142021The Voltage-Gated Sodium Channel Beta4 Subunit Maintains Epithelial Phenotype in Mammary Cells.2
328333402021Silencing of microRNA-3175 represses cell proliferation and invasion in prostate cancer by targeting the potential tumor-suppressor SCN4B.4
342096142021The Voltage-Gated Sodium Channel Beta4 Subunit Maintains Epithelial Phenotype in Mammary Cells.2
308213582019Significant association of rare variant p.Gly8Ser in cardiac sodium channel β4-subunit SCN4B with atrial fibrillation.13
310204142019Identification of rare variants in cardiac sodium channel β4-subunit gene SCN4B associated with ventricular tachycardia.3
308213582019Significant association of rare variant p.Gly8Ser in cardiac sodium channel β4-subunit SCN4B with atrial fibrillation.13
310204142019Identification of rare variants in cardiac sodium channel β4-subunit gene SCN4B associated with ventricular tachycardia.3
297233022018Preserved SCN4B expression is an independent indicator of favorable recurrence-free survival in classical papillary thyroid cancer.15
301903092018Structure of the human voltage-gated sodium channel Na(v)1.4 in complex with β1.196
297233022018Preserved SCN4B expression is an independent indicator of favorable recurrence-free survival in classical papillary thyroid cancer.15

Citation

Dessen P

SCN4B (sodium voltage-gated channel beta subunit 4)

Atlas Genet Cytogenet Oncol Haematol. 2018-11-01

Online version: http://atlasgeneticsoncology.org/gene/57725/gene-fusions-explorer/img/logo-atlas-4.svg