KLHL22 (kelch like family member 22)

2018-12-01  

Identity

HGNC
LOCATION
22q11.21
LOCUSID
ALIAS
KELCHL
FUSION GENES

Other Information

Locus ID:

NCBI: 84861
MIM: 618020
HGNC: 25888
Ensembl: ENSG00000099910

Variants:

dbSNP: 84861
ClinVar: 84861
TCGA: ENSG00000099910
COSMIC: KLHL22

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000099910ENST00000328879Q53GT1
ENSG00000099910ENST00000423364C9JRG9
ENSG00000099910ENST00000431430C9JLE9
ENSG00000099910ENST00000443285C9J5F8
ENSG00000099910ENST00000444967C9JHG1
ENSG00000099910ENST00000451553C9J191
ENSG00000099910ENST00000458248C9J2T1

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

References

Pubmed IDYearTitleCitations
324846972020KLHL22 promotes malignant melanoma growth in vitro and in vivo by activating the PI3K/Akt/mTOR signaling pathway.4
331097192020KLHL22 maintains PD-1 homeostasis and prevents excessive T cell suppression.29
324846972020KLHL22 promotes malignant melanoma growth in vitro and in vivo by activating the PI3K/Akt/mTOR signaling pathway.4
331097192020KLHL22 maintains PD-1 homeostasis and prevents excessive T cell suppression.29
297697192018KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing.58
297697192018KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing.58
240673712013CUL3 and protein kinases: insights from PLK1/KLHL22 interaction.12
240673712013CUL3 and protein kinases: insights from PLK1/KLHL22 interaction.12

Citation

Dessen P

KLHL22 (kelch like family member 22)

Atlas Genet Cytogenet Oncol Haematol. 2018-12-01

Online version: http://atlasgeneticsoncology.org/gene/57774/gene-explorer/js/lib/zoomerang.js