TMEM106B (transmembrane protein 106B)

2019-04-01  

Identity

HGNC
LOCATION
7p21.3
LOCUSID
ALIAS
HLD16
FUSION GENES

Other Information

Locus ID:

NCBI: 54664
MIM: 613413
HGNC: 22407
Ensembl: ENSG00000106460

Variants:

dbSNP: 54664
ClinVar: 54664
TCGA: ENSG00000106460
COSMIC: TMEM106B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106460ENST00000396667Q9NUM4
ENSG00000106460ENST00000396667A0A024R9Z1
ENSG00000106460ENST00000396668Q9NUM4
ENSG00000106460ENST00000396668A0A024R9Z1
ENSG00000106460ENST00000420833F2Z3N7
ENSG00000106460ENST00000442107C9J998
ENSG00000106460ENST00000444443C9JZ87

Expression (GTEx)

0
5
10
15

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
382321382024TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia.4
386743512024Association of TMEM106B with Cortical APOE Gene Expression in Neurodegenerative Conditions.0
387109672024Physiological and pathological functions of TMEM106B in neurodegenerative diseases.0
389242472024A common Alu insertion in the 3'UTR of TMEM106B is associated with risk of dementia.1
382321382024TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia.4
386743512024Association of TMEM106B with Cortical APOE Gene Expression in Neurodegenerative Conditions.0
387109672024Physiological and pathological functions of TMEM106B in neurodegenerative diseases.0
389242472024A common Alu insertion in the 3'UTR of TMEM106B is associated with risk of dementia.1
365274862023Accumulation of TMEM106B C-terminal fragments in neurodegenerative disease and aging.22
371000872023C-terminal TMEM106B fragments in human brain correlate with disease-associated TMEM106B haplotypes.8
371297662023Superresolution live-cell imaging reveals that the localization of TMEM106B to filopodia in oligodendrocytes is compromised by the hypomyelination-related D252N mutation.0
374219492023TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry.30
375306442023TMEM106B Fibrils from FTLD Patients and Healthy Controls.0
375637052023TMEM106B aggregation in neurodegenerative diseases: linking genetics to function.3
377268342023The major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus.9

Citation

Dessen P

TMEM106B (transmembrane protein 106B)

Atlas Genet Cytogenet Oncol Haematol. 2019-04-01

Online version: http://atlasgeneticsoncology.org/gene/57836/img/css/card-gene.css