ADPRS (ADP-ribosylserine hydrolase)

2019-04-01  

Identity

HGNC
LOCATION
1p34.3
LOCUSID
ALIAS
ADPRHL2,ARH3,CONDSIAS

Other Information

Locus ID:

NCBI: 54936
MIM: 610624
HGNC: 21304
Ensembl: ENSG00000116863

Variants:

dbSNP: 54936
ClinVar: 54936
TCGA: ENSG00000116863
COSMIC: ADPRS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116863ENST00000373178Q9NX46

References

Pubmed IDYearTitleCitations
162782112006Identification and characterization of a mammalian 39-kDa poly(ADP-ribose) glycohydrolase.106
286503172017Serine ADP-ribosylation reversal by the hydrolase ARH3.47
170750462006The 39-kDa poly(ADP-ribose) glycohydrolase ARH3 hydrolyzes O-acetyl-ADP-ribose, a product of the Sir2 family of acetyl-histone deacetylases.46
170158232006The structure of human ADP-ribosylhydrolase 3 (ARH3) provides insights into the reversibility of protein ADP-ribosylation.45
224338482012ADP-ribosylhydrolase 3 (ARH3), not poly(ADP-ribose) glycohydrolase (PARG) isoforms, is responsible for degradation of mitochondrial matrix-associated poly(ADP-ribose).41
294808022018Serine is the major residue for ADP-ribosylation upon DNA damage.36
292340052017Proteomic analyses identify ARH3 as a serine mono-ADP-ribosylhydrolase.27
304014612018Bi-allelic ADPRHL2 Mutations Cause Neurodegeneration with Developmental Delay, Ataxia, and Axonal Neuropathy.8
165113072006Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of human ARH3, the first eukaryotic protein-ADP-ribosylhydrolase.7
300458702018Structure-function analyses reveal the mechanism of the ARH3-dependent hydrolysis of ADP-ribosylation.7

Citation

Dessen P

ADPRS (ADP-ribosylserine hydrolase)

Atlas Genet Cytogenet Oncol Haematol. 2019-04-01

Online version: http://atlasgeneticsoncology.org/gene/57887/adprs-(adp-ribosylserine-hydrolase)