GET3 (guided entry of tail-anchored proteins factor 3, ATPase)

2019-05-01  

Identity

HGNC
GET3
LOCATION
19p13.13
LOCUSID
439
ALIAS
ARSA-I,ARSA1,ASNA-I,ASNA1,TRC40

Other Information

Locus ID:

NCBI: 439
MIM: 601913
HGNC: 752
Ensembl: ENSG00000198356

Variants:

dbSNP: 439
ClinVar: 439
TCGA: ENSG00000198356
COSMIC: GET3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198356ENST00000357332O43681
ENSG00000198356ENST00000591090O43681

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Unfolded Protein Response (UPR)REACTOMER-HSA-381119
IRE1alpha activates chaperonesREACTOMER-HSA-381070
XBP1(S) activates chaperone genesREACTOMER-HSA-381038

References

Pubmed IDYearTitleCitations
311826452019A trap mutant reveals the physiological client spectrum of TRC40.11
314613012019Biallelic Variants in ASNA1, Encoding a Cytosolic Targeting Factor of Tail-Anchored Proteins, Cause Rapidly Progressive Pediatric Cardiomyopathy.9
311826452019A trap mutant reveals the physiological client spectrum of TRC40.11
314613012019Biallelic Variants in ASNA1, Encoding a Cytosolic Targeting Factor of Tail-Anchored Proteins, Cause Rapidly Progressive Pediatric Cardiomyopathy.9
266752332016Emery-Dreifuss muscular dystrophy mutations impair TRC40-mediated targeting of emerin to the inner nuclear membrane.19
272265392016Tail-anchored Protein Insertion in Mammals: FUNCTION AND RECIPROCAL INTERACTIONS OF THE TWO SUBUNITS OF THE TRC40 RECEPTOR.16
274581902016Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing.0
277650462016Asna1/TRC40 that mediates membrane insertion of tail-anchored proteins is required for efficient release of Herpes simplex virus 1 virions.6
266752332016Emery-Dreifuss muscular dystrophy mutations impair TRC40-mediated targeting of emerin to the inner nuclear membrane.19
272265392016Tail-anchored Protein Insertion in Mammals: FUNCTION AND RECIPROCAL INTERACTIONS OF THE TWO SUBUNITS OF THE TRC40 RECEPTOR.16
274581902016Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing.0
277650462016Asna1/TRC40 that mediates membrane insertion of tail-anchored proteins is required for efficient release of Herpes simplex virus 1 virions.6
248851472014VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase.22
248851472014VAPB/ALS8 interacts with FFAT-like proteins including the p97 cofactor FAF1 and the ASNA1 ATPase.22
234606772013Tail-anchored PEX26 targets peroxisomes via a PEX19-dependent and TRC40-independent class I pathway.47

Citation

Dessen P

GET3 (guided entry of tail-anchored proteins factor 3, ATPase)

Atlas Genet Cytogenet Oncol Haematol. 2019-05-01

Online version: http://atlasgeneticsoncology.org/gene/57981/gene-explorer/css/js/_common.js