TNRC6C (trinucleotide repeat containing adaptor 6C)

2019-08-01  

Identity

HGNC
LOCATION
17q25.3
LOCUSID
ALIAS
-

Other Information

Locus ID:

NCBI: 57690
MIM: 610741
HGNC: 29318
Ensembl: ENSG00000078687

Variants:

dbSNP: 57690
ClinVar: 57690
TCGA: ENSG00000078687
COSMIC: TNRC6C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000078687ENST00000301624Q9HCJ0
ENSG00000078687ENST00000335749Q9HCJ0
ENSG00000078687ENST00000585438K7ELY5
ENSG00000078687ENST00000588061Q9HCJ0
ENSG00000078687ENST00000588549K7EKN9
ENSG00000078687ENST00000588847Q9HCJ0
ENSG00000078687ENST00000636222A0A1B0GU24

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Signaling by the B Cell Receptor (BCR)REACTOMER-HSA-983705
Downstream signaling events of B Cell Receptor (BCR)REACTOMER-HSA-1168372
PIP3 activates AKT signalingREACTOMER-HSA-1257604
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127
DAP12 signalingREACTOMER-HSA-2424491
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
Role of LAT2/NTAL/LAB on calcium mobilizationREACTOMER-HSA-2730905
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
GAB1 signalosomeREACTOMER-HSA-180292
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
PI3K/AKT activationREACTOMER-HSA-198203
Signaling by PDGFREACTOMER-HSA-186797
Downstream signal transductionREACTOMER-HSA-186763
Signaling by SCF-KITREACTOMER-HSA-1433557
MAPK family signaling cascadesREACTOMER-HSA-5683057
MAPK6/MAPK4 signalingREACTOMER-HSA-5687128
Signaling by NOTCHREACTOMER-HSA-157118
Pre-NOTCH Expression and ProcessingREACTOMER-HSA-1912422
Pre-NOTCH Transcription and TranslationREACTOMER-HSA-1912408
Signaling by WntREACTOMER-HSA-195721
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
Ca2+ pathwayREACTOMER-HSA-4086398
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
TP53 Regulates Metabolic GenesREACTOMER-HSA-5628897
Gene Silencing by RNAREACTOMER-HSA-211000
Post-transcriptional silencing by small RNAsREACTOMER-HSA-426496
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Oncogene Induced SenescenceREACTOMER-HSA-2559585
Oxidative Stress Induced SenescenceREACTOMER-HSA-2559580

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
193837682009The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins.73
193049252009Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression.66
200984212010Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation.49
210633882010Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing.43
309380302019Suppression of long non-coding RNA TNRC6C-AS1 protects against thyroid carcinoma through DNA demethylation of STK4 via the Hippo signalling pathway.3
309975012019TNRC6 proteins modulate hepatitis C virus replication by spatially regulating the binding of miR-122/Ago2 complexes to viral RNA.3

Citation

Dessen P

TNRC6C (trinucleotide repeat containing adaptor 6C)

Atlas Genet Cytogenet Oncol Haematol. 2019-08-01

Online version: http://atlasgeneticsoncology.org/gene/58045/tnrc6c