KREMEN2 (kringle containing transmembrane protein 2)

2019-08-01  

Identity

HGNC
LOCATION
16p13.3
LOCUSID
ALIAS
KRM2

Other Information

Locus ID:

NCBI: 79412
MIM: 609899
HGNC: 18797
Ensembl: ENSG00000131650

Variants:

dbSNP: 79412
ClinVar: 79412
TCGA: ENSG00000131650
COSMIC: KREMEN2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131650ENST00000303746Q8NCW0

Expression (GTEx)

0
1
2
3
4
5
6
7

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Signaling by WNT in cancerREACTOMER-HSA-4791275
Misspliced LRP5 mutants have enhanced beta-catenin-dependent signalingREACTOMER-HSA-5339717
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Negative regulation of TCF-dependent signaling by WNT ligand antagonistsREACTOMER-HSA-3772470

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
386157312024N(6)-Methyladenosine-Modified KREMEN2 Promotes Tumorigenesis and Malignant Progression of High-Grade Serous Ovarian Cancer.0
386157312024N(6)-Methyladenosine-Modified KREMEN2 Promotes Tumorigenesis and Malignant Progression of High-Grade Serous Ovarian Cancer.0
310691162019Kremen1-induced cell death is regulated by homo- and heterodimerization.11
310691162019Kremen1-induced cell death is regulated by homo- and heterodimerization.11
208463892010Differential expression of DKK-1 binding receptors on stromal cells and myeloma cells results in their distinct response to secreted DKK-1 in myeloma.10
208463892010Differential expression of DKK-1 binding receptors on stromal cells and myeloma cells results in their distinct response to secreted DKK-1 in myeloma.10

Citation

Dessen P

KREMEN2 (kringle containing transmembrane protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2019-08-01

Online version: http://atlasgeneticsoncology.org/gene/58095/cancer-prone-explorer/css/template-card.css