SLC25A11 (solute carrier family 25 member 11)

2019-08-01  

Identity

HGNC
SLC25A11
LOCATION
17p13.2
LOCUSID
8402
ALIAS
OGC,PGL6,SLC20A4

Other Information

Locus ID:

NCBI: 8402
MIM: 604165
HGNC: 10981
Ensembl: ENSG00000108528

Variants:

dbSNP: 8402
ClinVar: 8402
TCGA: ENSG00000108528
COSMIC: SLC25A11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000108528ENST00000225665Q02978
ENSG00000108528ENST00000225665Q6IBH0
ENSG00000108528ENST00000544061Q02978
ENSG00000108528ENST00000576951I3L1P8

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glucose metabolismREACTOMER-HSA-70326
GluconeogenesisREACTOMER-HSA-70263

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
306867542019Loss of SLC25A11 causes suppression of NSCLC and melanoma tumor formation.22
306867542019Loss of SLC25A11 causes suppression of NSCLC and melanoma tumor formation.22
294316362018Germline Mutations in the Mitochondrial 2-Oxoglutarate/Malate Carrier SLC25A11 Gene Confer a Predisposition to Metastatic Paragangliomas.57
294316362018Germline Mutations in the Mitochondrial 2-Oxoglutarate/Malate Carrier SLC25A11 Gene Confer a Predisposition to Metastatic Paragangliomas.57
282422972017Systems biology approach to late-onset Alzheimer's disease genome-wide association study identifies novel candidate genes validated using brain expression data and Caenorhabditis elegans experiments.27
282422972017Systems biology approach to late-onset Alzheimer's disease genome-wide association study identifies novel candidate genes validated using brain expression data and Caenorhabditis elegans experiments.27
230540772013The mitochondrial oxoglutarate carrier: from identification to mechanism.24
232661872013The mitochondrial transporter family SLC25: identification, properties and physiopathology.0
230540772013The mitochondrial oxoglutarate carrier: from identification to mechanism.24
232661872013The mitochondrial transporter family SLC25: identification, properties and physiopathology.0
214484542011MISC-1/OGC links mitochondrial metabolism, apoptosis and insulin secretion.15
215005442011[Metabolic pathways of OGCP and the influence of parkin protein on the metabolism of OGCP].0
214484542011MISC-1/OGC links mitochondrial metabolism, apoptosis and insulin secretion.15
215005442011[Metabolic pathways of OGCP and the influence of parkin protein on the metabolism of OGCP].0
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15

Citation

Dessen P

SLC25A11 (solute carrier family 25 member 11)

Atlas Genet Cytogenet Oncol Haematol. 2019-08-01

Online version: http://atlasgeneticsoncology.org/gene/58116/favicon/css/lib/js/favicon/favicon-16x16.png