AGR2 (anterior gradient 2, protein disulphide isomerase family member)

2003-02-01  

Identity

HGNC
LOCATION
7p21.1
LOCUSID
ALIAS
AG-2,AG2,GOB-4,HAG-2,HEL-S-116,HPC8,PDIA17,XAG-2
FUSION GENES

Other Information

Locus ID:

NCBI: 10551
MIM: 606358
HGNC: 328
Ensembl: ENSG00000106541

Variants:

dbSNP: 10551
ClinVar: 10551
TCGA: ENSG00000106541
COSMIC: AGR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106541ENST00000401412B5MC07
ENSG00000106541ENST00000412973C9J3E2
ENSG00000106541ENST00000419304O95994
ENSG00000106541ENST00000419304Q4JM46
ENSG00000106541ENST00000450569H7C3Z9

Expression (GTEx)

0
50
100
150
200
250
300

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
188295362008Anterior gradient 2 is expressed and secreted during the development of pancreatic cancer and promotes cancer cell survival.64
125923732003hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan.52
158349402005AGR2, an androgen-inducible secretory protein overexpressed in prostate cancer.48
219489702011AGR2 is a novel surface antigen that promotes the dissemination of pancreatic cancer cells through regulation of cathepsins B and D.46
229456522013Emerging roles for the pro-oncogenic anterior gradient-2 in cancer development.45
159357012005Diversity of the protein disulfide isomerase family: identification of breast tumor induced Hag2 and Hag3 as novel members of the protein family.41
162223432006Evaluation of AGR2 and AGR3 as candidate genes for inflammatory bowel disease.40
162223432006Evaluation of AGR2 and AGR3 as candidate genes for inflammatory bowel disease.40
165518562006Prognostic relevance of AGR2 expression in breast cancer.39
214545162011The human adenocarcinoma-associated gene, AGR2, induces expression of amphiregulin through Hippo pathway co-activator YAP1 activation.38

Citation

Dessen P

AGR2 (anterior gradient 2, protein disulphide isomerase family member)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/595/agr2-(anterior-gradient-2-protein-disulphide-isomerase-family-member)