AHSA1 (activator of HSP90 ATPase activity 1)

2003-05-01  

Identity

HGNC
LOCATION
14q24.3
LOCUSID
ALIAS
AHA1,C14orf3,hAha1,p38
FUSION GENES

Other Information

Locus ID:

NCBI: 10598
MIM: 608466
HGNC: 1189
Ensembl: ENSG00000100591

Variants:

dbSNP: 10598
ClinVar: 10598
TCGA: ENSG00000100591
COSMIC: AHSA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100591ENST00000216479O95433
ENSG00000100591ENST00000535854O95433
ENSG00000100591ENST00000553374H0YJG7
ENSG00000100591ENST00000555133G3V438
ENSG00000100591ENST00000555517G3V3W9
ENSG00000100591ENST00000555729H0YJU2
ENSG00000100591ENST00000556369H0YJ63

Expression (GTEx)

0
50
100
150

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
171103382006Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis.260
125040072002Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1.168
200898312010Biological and structural basis for Aha1 regulation of Hsp90 ATPase activity in maintaining proteostasis in the human disease cystic fibrosis.61
227276662012Dynamic tyrosine phosphorylation modulates cycling of the HSP90-P50(CDC37)-AHA1 chaperone machine.50
288273212017Hsp90 activator Aha1 drives production of pathological tau aggregates.12
225041722012Characterization of the interaction of Aha1 with components of the Hsp90 chaperone machine and client proteins.11
254864572015Middle domain of human Hsp90 isoforms differentially binds Aha1 in human cells and alters Hsp90 activity in yeast.8
228594912012Modulation of the cochaperone AHA1 regulates heat-shock protein 90 and endothelial NO synthase activation by vascular endothelial growth factor.6
253784002014Aha1 can act as an autonomous chaperone to prevent aggregation of stressed proteins.4
312991342019Dynamic Aha1 co-chaperone binding to human Hsp90.1

Citation

Dessen P

AHSA1 (activator of HSP90 ATPase activity 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/599/ahsa1-(activator-of-hsp90-atpase-activity-1)