IL3 (interleukin-3)

1999-12-01   Jean-Loup Huret  

Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Identity

HGNC
IL3
LOCATION
5q31.1
LOCUSID
3562
ALIAS
IL-3,MCGF,MULTI-CSF
FUSION GENES
Show Gene Fusions

DNA/RNA

Description

5 exons

Transcription

674 bp transcript with a 458 bp of coding sequence

Proteins

Description

152 amino acids; 17 kDa

Expression

IL3 is produced by activated T cells, monocytes/macrophages and stroma cells

Function

cytokine; multipotent hematopoietic growth factor; induces proliferation, maturation and probably self-renewal of pluripotent hematopoietic stem cells and cells of myeloid, erythroid and megakaryocytic lineages; IL-3 plays a more specialized role on basophil and mast cells; role through activation of the IL-3 receptor (IL-3R) complex consisting of alpha and beta subunits, which in turn induces activation of JAK2/ STAT5 , and induction of c-myc (cell-cycle progression and DNA synthesis), and activation of the Ras pathway (suppression of apoptosis); IL3 and GM-CSF have overlapping but distinct biological properties

Implicated in

Entity name
t(5;14)(q31;q32)
Disease
B-cell acute lymphoblastic leukemia (ALL) with hypereosinophilia
Prognosis
poor
Cytogenetics
t(5;14) may be the sole anomaly or accompanied with other anomalies
Hybrid gene
break in the promoter region of IL3 and in the Jh region of IgH
Fusion protein
the immunoglobulin gene promoter controls the expression of IL3
Oncogenesis
over-expression of IL3

Article Bibliography

Pubmed IDLast YearTitleAuthors
96641561998The physiologic role of interleukin-3, interleukin-5, granulocyte-macrophage colony-stimulating factor, and the beta c receptor system.Burdach S et al
24993621989The t(5;14) chromosomal translocation in a case of acute lymphocytic leukemia joins the interleukin-3 gene to the immunoglobulin heavy chain gene.Grimaldi JC et al
89480191996Function and signal transduction mediated by the interleukin 3 receptor system in hematopoiesis.Hara T et al
105156811999Interleukin-3 in hematology and oncology: current state of knowledge and future directions.Mangi MH et al
75498901995Regulation of granulocyte-macrophage colony-stimulating factor and interleukin 3 expression.Nimer SD et al
34895301986Human IL-3 (multi-CSF): identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3.Yang YC et al

Other Information

Locus ID:

NCBI: 3562
MIM: 147740
HGNC: 6011
Ensembl: ENSG00000164399

Variants:

dbSNP: 3562
ClinVar: 3562
TCGA: ENSG00000164399
COSMIC: IL3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164399ENST00000296870P08700

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
ApoptosisKEGGko04210
Jak-STAT signaling pathwayKEGGko04630
Hematopoietic cell lineageKEGGko04640
Fc epsilon RI signaling pathwayKEGGko04664
AsthmaKEGGko05310
Cytokine-cytokine receptor interactionKEGGhsa04060
ApoptosisKEGGhsa04210
Jak-STAT signaling pathwayKEGGhsa04630
Hematopoietic cell lineageKEGGhsa04640
Fc epsilon RI signaling pathwayKEGGhsa04664
AsthmaKEGGhsa05310
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127
DAP12 signalingREACTOMER-HSA-2424491
RAF/MAP kinase cascadeREACTOMER-HSA-5673001
Fc epsilon receptor (FCERI) signalingREACTOMER-HSA-2454202
FCERI mediated MAPK activationREACTOMER-HSA-2871796
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-2 signalingREACTOMER-HSA-451927
Interleukin receptor SHC signalingREACTOMER-HSA-912526
Interleukin-3, 5 and GM-CSF signalingREACTOMER-HSA-512988
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
GPVI-mediated activation cascadeREACTOMER-HSA-114604
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
GRB2 events in EGFR signalingREACTOMER-HSA-179812
SHC1 events in EGFR signalingREACTOMER-HSA-180336
Signaling by Insulin receptorREACTOMER-HSA-74752
Insulin receptor signalling cascadeREACTOMER-HSA-74751
IRS-mediated signallingREACTOMER-HSA-112399
SOS-mediated signallingREACTOMER-HSA-112412
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
Signalling to ERKsREACTOMER-HSA-187687
Signalling to RASREACTOMER-HSA-167044
Signalling to p38 via RIT and RINREACTOMER-HSA-187706
Prolonged ERK activation eventsREACTOMER-HSA-169893
Frs2-mediated activationREACTOMER-HSA-170968
ARMS-mediated activationREACTOMER-HSA-170984
Signaling by PDGFREACTOMER-HSA-186797
Downstream signal transductionREACTOMER-HSA-186763
Signaling by VEGFREACTOMER-HSA-194138
VEGFA-VEGFR2 PathwayREACTOMER-HSA-4420097
VEGFR2 mediated cell proliferationREACTOMER-HSA-5218921
Signaling by SCF-KITREACTOMER-HSA-1433557
MAPK family signaling cascadesREACTOMER-HSA-5683057
MAPK1/MAPK3 signalingREACTOMER-HSA-5684996
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G-protein beta:gamma signallingREACTOMER-HSA-397795
G beta:gamma signalling through PI3KgammaREACTOMER-HSA-392451
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)REACTOMER-HSA-2404192
IGF1R signaling cascadeREACTOMER-HSA-2428924
IRS-related events triggered by IGF1RREACTOMER-HSA-2428928
Signaling by LeptinREACTOMER-HSA-2586552
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
NCAM signaling for neurite out-growthREACTOMER-HSA-375165
RET signalingREACTOMER-HSA-8853659

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA165817016Kidney TransplantationDiseaseClinicalAnnotationassociatedPK
PA451578tacrolimusChemicalClinicalAnnotationassociatedPK

References

Pubmed IDYearTitleCitations
367290882023Conformational and binding mode assessment of the human IL-3 recognition by its alpha receptor.0
369117372023Interleukin-3 protects against viral pneumonia in sepsis by enhancing plasmacytoid dendritic cell recruitment into the lungs and T cell priming.3
371601172023Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis.4
374533422023Quantitative estimation of TNF-α and IL-3 by using ELISA from human lung tissue in fatal asphyxial deaths.1
367290882023Conformational and binding mode assessment of the human IL-3 recognition by its alpha receptor.0
369117372023Interleukin-3 protects against viral pneumonia in sepsis by enhancing plasmacytoid dendritic cell recruitment into the lungs and T cell priming.3
371601172023Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis.4
374533422023Quantitative estimation of TNF-α and IL-3 by using ELISA from human lung tissue in fatal asphyxial deaths.1
345068502022Demonstration and implications of IL-3 upregulation of CD25 expression on human mast cells.0
346194172022The association between serum level and genetic variation of IL-3 (rs40401) in recurrent abortion women infected with toxoplasmosis in Iraq.0
352810142022An Immunoregulatory Role of Interleukin-3 in Allergic Asthma.8
345068502022Demonstration and implications of IL-3 upregulation of CD25 expression on human mast cells.0
346194172022The association between serum level and genetic variation of IL-3 (rs40401) in recurrent abortion women infected with toxoplasmosis in Iraq.0
352810142022An Immunoregulatory Role of Interleukin-3 in Allergic Asthma.8
323274992021A 3D iPSC-differentiation model identifies interleukin-3 as a regulator of early human hematopoietic specification.11

Citation

Jean-Loup Huret

IL3 (interleukin-3)

Atlas Genet Cytogenet Oncol Haematol. 1999-12-01

Online version: http://atlasgeneticsoncology.org/gene/60/css/cancer-prone-explorer/js/template.js