ACOT12 (acyl-CoA thioesterase 12)

2014-11-01  

Identity

HGNC
ACOT12
LOCATION
5q14.1
LOCUSID
134526
ALIAS
CACH-1,Cach,STARD15,THEAL
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 134526
MIM: 614315
HGNC: 24436
Ensembl: ENSG00000172497

Variants:

dbSNP: 134526
ClinVar: 134526
TCGA: ENSG00000172497
COSMIC: ACOT12

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172497ENST00000307624Q8WYK0
ENSG00000172497ENST00000513751Q8WYK0

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Pyruvate metabolismKEGGko00620
Pyruvate metabolismKEGGhsa00620
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Triglyceride BiosynthesisREACTOMER-HSA-75109
Fatty Acyl-CoA BiosynthesisREACTOMER-HSA-75105

References

Pubmed IDYearTitleCitations
359860102022Exosomal miR-155-5p derived from glioma stem-like cells promotes mesenchymal transition via targeting ACOT12.0
359860102022Exosomal miR-155-5p derived from glioma stem-like cells promotes mesenchymal transition via targeting ACOT12.0
342853352021Loss of Acot12 contributes to NAFLD independent of lipolysis of adipose tissue.4
342853352021Loss of Acot12 contributes to NAFLD independent of lipolysis of adipose tissue.4
318587482020Variation at ACOT12 and CT62 locus represents susceptibility to psoriasis in Han population.2
318587482020Variation at ACOT12 and CT62 locus represents susceptibility to psoriasis in Han population.2
306619302019ACOT12-Dependent Alteration of Acetyl-CoA Drives Hepatocellular Carcinoma Metastasis by Epigenetic Induction of Epithelial-Mesenchymal Transition.68
306619302019ACOT12-Dependent Alteration of Acetyl-CoA Drives Hepatocellular Carcinoma Metastasis by Epigenetic Induction of Epithelial-Mesenchymal Transition.68
250025762014Structural basis for regulation of the human acetyl-CoA thioesterase 12 and interactions with the steroidogenic acute regulatory protein-related lipid transfer (START) domain.13
250025762014Structural basis for regulation of the human acetyl-CoA thioesterase 12 and interactions with the steroidogenic acute regulatory protein-related lipid transfer (START) domain.13
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
169517432006Molecular cloning and functional expression of human cytosolic acetyl-CoA hydrolase.15
169517432006Molecular cloning and functional expression of human cytosolic acetyl-CoA hydrolase.15

Citation

Dessen P

ACOT12 (acyl-CoA thioesterase 12)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/60088/js/css/lib/bootstrap.min.css