ANAPC16 (anaphase promoting complex subunit 16)

2014-11-01  

Identity

HGNC
LOCATION
10q22.1
LOCUSID
ALIAS
APC16,C10orf104,CENP-27,MSAG,bA570G20.3
FUSION GENES

Other Information

Locus ID:

NCBI: 119504
MIM: 613427
HGNC: 26976
Ensembl: ENSG00000166295

Variants:

dbSNP: 119504
ClinVar: 119504
TCGA: ENSG00000166295
COSMIC: ANAPC16

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166295ENST00000299381Q96DE5
ENSG00000166295ENST00000299381C5H3H2
ENSG00000166295ENST00000615507A0A087WUN5
ENSG00000166295ENST00000621663Q96DE5
ENSG00000166295ENST00000621663C5H3H2

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
Mitotic Spindle CheckpointREACTOMER-HSA-69618
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint componentsREACTOMER-HSA-141405
Inactivation of APC/C via direct inhibition of the APC/C complexREACTOMER-HSA-141430
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
Regulation of mitotic cell cycleREACTOMER-HSA-453276
APC/C-mediated degradation of cell cycle proteinsREACTOMER-HSA-174143
Regulation of APC/C activators between G1/S and early anaphaseREACTOMER-HSA-176408
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteinsREACTOMER-HSA-176814
Phosphorylation of the APC/CREACTOMER-HSA-176412
APC/C:Cdc20 mediated degradation of mitotic proteinsREACTOMER-HSA-176409
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpointREACTOMER-HSA-179419
Cdc20:Phospho-APC/C mediated degradation of Cyclin AREACTOMER-HSA-174184
APC-Cdc20 mediated degradation of Nek2AREACTOMER-HSA-179409
APC/C:Cdc20 mediated degradation of Cyclin BREACTOMER-HSA-174048
APC/C:Cdc20 mediated degradation of SecurinREACTOMER-HSA-174154
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphaseREACTOMER-HSA-176407
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1REACTOMER-HSA-174178
Autodegradation of Cdh1 by Cdh1:APC/CREACTOMER-HSA-174084
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Senescence-Associated Secretory Phenotype (SASP)REACTOMER-HSA-2559582

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
254902582015Structure of an APC3-APC16 complex: insights into assembly of the anaphase-promoting complex/cyclosome.17
192320442009Identification of a novel gene, MSAG, regulated by high levels of glucose and insulin.1
304858022018Deletion of APC7 or APC16 Allows Proliferation of Human Cells without the Spindle Assembly Checkpoint.1

Citation

Dessen P

ANAPC16 (anaphase promoting complex subunit 16)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/60290/anapc16-(anaphase-promoting-complex-subunit-16)