ARL5B (ADP ribosylation factor like GTPase 5B)

ARL5B (ADP ribosylation factor like GTPase 5B)

2014-11-01 Affiliation

Identity

HGNC

LOCATION

10p12.31

LOCUSID

ALIAS

ARL8

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 221079
MIM: 608909
HGNC: 23052
Ensembl: ENSG00000165997

Variants:

dbSNP: 221079
ClinVar: 221079
TCGA: ENSG00000165997
COSMIC: ARL5B

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000165997	ENST00000377275	Q96KC2
ENSG00000165997	ENST00000377275	B0YIW9

Expression (GTEx)

0

5

10

15

20

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
35546774	2022	Knockdown of ARL5B Induces Mitochondrial-mediated Apoptosis and Inhibits Glycolysis in Breast Cancer Cells by Activating MDA5 Signaling.	0
35789482	2022	Interacting partners of Golgi-localized small G protein Arl5b identified by a combination of in vivo proximity labelling and GFP-Trap pull down.	2
35546774	2022	Knockdown of ARL5B Induces Mitochondrial-mediated Apoptosis and Inhibits Glycolysis in Breast Cancer Cells by Activating MDA5 Signaling.	0
35789482	2022	Interacting partners of Golgi-localized small G protein Arl5b identified by a combination of in vivo proximity labelling and GFP-Trap pull down.	2
33419459	2021	miR-145 inhibits mitochondrial function of ovarian cancer by targeting ARL5B.	8
34798070	2021	Binding with heat shock cognate protein HSC70 fine-tunes the Golgi association of the small GTPase ARL5B.	0
33419459	2021	miR-145 inhibits mitochondrial function of ovarian cancer by targeting ARL5B.	8
34798070	2021	Binding with heat shock cognate protein HSC70 fine-tunes the Golgi association of the small GTPase ARL5B.	0
32250445	2020	Advanced glycation end products reduce macrophage-mediated killing of Staphylococcus aureus by ARL8 upregulation and inhibition of autolysosome formation.	6
32250445	2020	Advanced glycation end products reduce macrophage-mediated killing of Staphylococcus aureus by ARL8 upregulation and inhibition of autolysosome formation.	6
28000370	2017	Amyloid precursor protein traffics from the Golgi directly to early endosomes in an Arl5b- and AP4-dependent pathway.	29
28000370	2017	Amyloid precursor protein traffics from the Golgi directly to early endosomes in an Arl5b- and AP4-dependent pathway.	29
22245584	2012	Arl5b is a Golgi-localised small G protein involved in the regulation of retrograde transport.	17
22245584	2012	Arl5b is a Golgi-localised small G protein involved in the regulation of retrograde transport.	17
22172677	2011	Arl8 and SKIP act together to link lysosomes to kinesin-1.	155

Citation

Dessen P

ARL5B (ADP ribosylation factor like GTPase 5B)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/60500/case-report-explorer/js/lib/bootstrap.min.js