CEP68 (centrosomal protein 68)

CEP68 (centrosomal protein 68)

2014-11-01 Affiliation

Identity

HGNC

LOCATION

2p14

LOCUSID

ALIAS

KIAA0582

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 23177
MIM: 616889
HGNC: 29076
Ensembl: ENSG00000011523

Variants:

dbSNP: 23177
ClinVar: 23177
TCGA: ENSG00000011523
COSMIC: CEP68

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000011523	ENST00000260569	Q76N32
ENSG00000011523	ENST00000377990	Q76N32
ENSG00000011523	ENST00000537589	Q5HYA6

Expression (GTEx)

0

5

10

15

20

25

30

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA443450	Asthma	Disease	ClinicalAnnotation	associated		PD
PA448497	aspirin	Chemical	ClinicalAnnotation	associated		PD

References

Pubmed ID	Year	Title	Citations
30093714	2019	Polymorphisms in CEP68 gene associated with risk of immediate selective reactions to non-steroidal anti-inflammatory drugs.	2
30093714	2019	Polymorphisms in CEP68 gene associated with risk of immediate selective reactions to non-steroidal anti-inflammatory drugs.	2
29463719	2018	STED nanoscopy of the centrosome linker reveals a CEP68-organized, periodic rootletin network anchored to a C-Nap1 ring at centrioles.	35
29463719	2018	STED nanoscopy of the centrosome linker reveals a CEP68-organized, periodic rootletin network anchored to a C-Nap1 ring at centrioles.	35
28089774	2017	Rootletin prevents Cep68 from VHL-mediated proteasomal degradation to maintain centrosome cohesion.	9
28578000	2017	Centrosomal MCM7 strengthens the Cep68-VHL interaction and excessive MCM7 leads to centrosome splitting resulting from increase in Cep68 ubiquitination and proteasomal degradation.	5
28089774	2017	Rootletin prevents Cep68 from VHL-mediated proteasomal degradation to maintain centrosome cohesion.	9
28578000	2017	Centrosomal MCM7 strengthens the Cep68-VHL interaction and excessive MCM7 leads to centrosome splitting resulting from increase in Cep68 ubiquitination and proteasomal degradation.	5
25503564	2015	Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing.	41
25704143	2015	Cep68 can be regulated by Nek2 and SCF complex.	14
25503564	2015	Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing.	41
25704143	2015	Cep68 can be regulated by Nek2 and SCF complex.	14
24554434	2014	Centlein mediates an interaction between C-Nap1 and Cep68 to maintain centrosome cohesion.	33
24618698	2014	Variants of CEP68 gene are associated with acute urticaria/angioedema induced by multiple non-steroidal anti-inflammatory drugs.	2
24554434	2014	Centlein mediates an interaction between C-Nap1 and Cep68 to maintain centrosome cohesion.	33

Citation

Dessen P

CEP68 (centrosomal protein 68)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/61727/js/lib/cancer-prone-explorer/js/web-card-_common.js