CHMP1B (charged multivesicular body protein 1B)

2014-11-01 Affiliation

Identity

HGNC

CHMP1B

LOCATION

18p11.21

LOCUSID

57132

ALIAS

C10orf2,C18-ORF2,C18orf2,CHMP1.5,Vps46-2,Vps46B,hVps46-2

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 57132
MIM: 606486
HGNC: 24287
Ensembl: ENSG00000255112

Variants:

dbSNP: 57132
ClinVar: 57132
TCGA: ENSG00000255112
COSMIC: CHMP1B

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000255112	ENST00000526991	Q7LBR1

Expression (GTEx)

100

150

200

250

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Endocytosis	KEGG	ko04144
Endocytosis	KEGG	hsa04144
ESCRT-III complex	KEGG	hsa_M00412
ESCRT-III complex	KEGG	M00412

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
35858336	2022	Friction-driven membrane scission by the human ESCRT-III proteins CHMP1B and IST1.	9
35858336	2022	Friction-driven membrane scission by the human ESCRT-III proteins CHMP1B and IST1.	9
32251413	2020	Membrane constriction and thinning by sequential ESCRT-III polymerization.	38
32251413	2020	Membrane constriction and thinning by sequential ESCRT-III polymerization.	38
21616915	2011	Calpain-7 binds to CHMP1B at its second α-helical region and forms a ternary complex with IST1.	3
21616915	2011	Calpain-7 binds to CHMP1B at its second α-helical region and forms a ternary complex with IST1.	3
19328558	2009	Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population.	14
19328558	2009	Case-control association study of 65 candidate genes revealed a possible association of a SNP of HTR5A to be a factor susceptible to bipolar disease in Bulgarian population.	14
18997780	2008	Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B.	118
18997780	2008	Structural basis for midbody targeting of spastin by the ESCRT-III protein CHMP1B.	118
17711858	2007	The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation.	74
17711858	2007	The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation.	74
16094257	2005	Association analysis of CHMP1.5 genetic variation and bipolar disorder.	1
16174732	2005	Structure and ESCRT-III protein interactions of the MIT domain of human VPS4A.	87
16094257	2005	Association analysis of CHMP1.5 genetic variation and bipolar disorder.	1

Citation

Dessen P

CHMP1B (charged multivesicular body protein 1B)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/61802/js/lib/deep-insight-explorer/css/template-nav.css