DCAF15 (DDB1 and CUL4 associated factor 15)

2014-11-01  

Identity

HGNC
DCAF15
LOCATION
19p13.12
LOCUSID
90379
ALIAS
C19orf72

Other Information

Locus ID:

NCBI: 90379
HGNC: 25095
Ensembl: ENSG00000132017

Variants:

dbSNP: 90379
ClinVar: 90379
TCGA: ENSG00000132017
COSMIC: DCAF15

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132017ENST00000254337Q66K64
ENSG00000132017ENST00000585468K7ELE9
ENSG00000132017ENST00000587307K7ERN0
ENSG00000132017ENST00000591802K7ENG0

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
389610542024DCAF15 control of cohesin dynamics sustains acute myeloid leukemia.0
389610542024DCAF15 control of cohesin dynamics sustains acute myeloid leukemia.0
338331312021Tumor suppressor DCAF15 inhibits epithelial-mesenchymal transition by targeting ZEB1 for proteasomal degradation in hepatocellular carcinoma.5
338331312021Tumor suppressor DCAF15 inhibits epithelial-mesenchymal transition by targeting ZEB1 for proteasomal degradation in hepatocellular carcinoma.5
316860312020Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15.64
318192722020Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex.71
322000252020Targeting the E3 ubiquitin ligases DCAF15 and cereblon for cancer therapy.9
327139462020In vivo target protein degradation induced by PROTACs based on E3 ligase DCAF15.25
316860312020Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15.64
318192722020Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex.71
322000252020Targeting the E3 ubiquitin ligases DCAF15 and cereblon for cancer therapy.9
327139462020In vivo target protein degradation induced by PROTACs based on E3 ligase DCAF15.25
283027932017Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.237
283027932017Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.237

Citation

Dessen P

DCAF15 (DDB1 and CUL4 associated factor 15)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62315/favicon/gene-fusions-explorer/js/lib/bootstrap.min.js