AMD1 (adenosylmethionine decarboxylase 1)

2003-06-01  

Identity

HGNC
LOCATION
6q21
LOCUSID
ALIAS
ADOMETDC,AMD,SAMDC
FUSION GENES

Other Information

Locus ID:

NCBI: 262
MIM: 180980
HGNC: 457
Ensembl: ENSG00000123505

Variants:

dbSNP: 262
ClinVar: 262
TCGA: ENSG00000123505
COSMIC: AMD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000123505ENST00000368876Q5VXN5
ENSG00000123505ENST00000368877Q5VXN5
ENSG00000123505ENST00000368882B4DZ60
ENSG00000123505ENST00000368885P17707
ENSG00000123505ENST00000451850F6R5I9

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Arginine and proline metabolismKEGGko00330
Arginine and proline metabolismKEGGhsa00330
Cysteine and methionine metabolismKEGGko00270
Cysteine and methionine metabolismKEGGhsa00270
Metabolic pathwaysKEGGhsa01100
Polyamine biosynthesis, arginine => agmatine => putrescine => spermidineKEGGhsa_M00133
Methionine salvage pathwayKEGGhsa_M00034
Methionine salvage pathwayKEGGM00034
Polyamine biosynthesis, arginine => agmatine => putrescine => spermidineKEGGM00133
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Metabolism of polyaminesREACTOMER-HSA-351202

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
196612362009Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes.107
172598612007S-adenosyl methionine and DNA methyltransferase-1 mRNA overexpression in psychosis.35
286582052017mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer.35
191611602009An association study of 45 folate-related genes in spina bifida: Involvement of cubilin (CUBN) and tRNA aspartic acid methyltransferase 1 (TRDMT1).30
206158902010A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk.20
220082212012Effects of histone modifications on increased expression of polyamine biosynthetic genes in suicide.17
293101202018AMD1 mRNA employs ribosome stalling as a mechanism for molecular memory formation.16
190532722008Structural basis for putrescine activation of human S-adenosylmethionine decarboxylase.15
232601692013Effects of promoter methylation on increased expression of polyamine biosynthetic genes in suicide.12
224967432012Genetic variant of AMD1 is associated with obesity in urban Indian children.11

Citation

Dessen P

AMD1 (adenosylmethionine decarboxylase 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/626/amd1-(adenosylmethionine-decarboxylase-1)