DUSP12 (dual specificity phosphatase 12)

2014-11-01  

Identity

HGNC
DUSP12
LOCATION
1q23.3
LOCUSID
11266
ALIAS
DUSP1,YVH1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11266
MIM: 604835
HGNC: 3067
Ensembl: ENSG00000081721

Variants:

dbSNP: 11266
ClinVar: 11266
TCGA: ENSG00000081721
COSMIC: DUSP12

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000081721ENST00000367943Q9UNI6
ENSG00000081721ENST00000464004V9GY92
ENSG00000081721ENST00000484291V9GY92
ENSG00000081721ENST00000490591V9GYV5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
201036242010Efficacious immune therapy in chronic myelogenous leukemia (CML) recognizes antigens that are expressed on CML progenitor cells.22
262882492015Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.17
189734752009The dual-specificity phosphatase hYVH1 interacts with Hsp70 and prevents heat-shock-induced cell death.11
195678742009Redox regulation of the human dual specificity phosphatase YVH1 through disulfide bond formation.11
169362142006Polymorphisms in the glucokinase-associated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are associated with type 2 diabetes.8
169362142006Polymorphisms in the glucokinase-associated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 linkage peak are associated with type 2 diabetes.8
212110132011Lack of association between genetic polymorphisms within DUSP12 - ATF6 locus and glucose metabolism related traits in a Chinese population.8
215219432011The dual-specificity phosphatase hYVH1 (DUSP12) is a novel modulator of cellular DNA content.8
182696852008Type 2 diabetes susceptibility genes on chromosome 1q21-24.7
215561302011Characterization of a human cell line stably over-expressing the candidate oncogene, dual specificity phosphatase 12.7

Citation

Dessen P

DUSP12 (dual specificity phosphatase 12)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62674/dusp12-(dual-specificity-phosphatase-12)