EDC4 (enhancer of mRNA decapping 4)

2014-11-01  

Identity

HGNC
LOCATION
16q22.1
LOCUSID
ALIAS
GE1,Ge-1,HEDL5,HEDLS,RCD-8,RCD8
FUSION GENES

Other Information

Locus ID:

NCBI: 23644
MIM: 606030
HGNC: 17157
Ensembl: ENSG00000038358

Variants:

dbSNP: 23644
ClinVar: 23644
TCGA: ENSG00000038358
COSMIC: EDC4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000038358ENST00000358933Q6P2E9
ENSG00000038358ENST00000573985I3L0V0
ENSG00000038358ENST00000575033I3L3M2
ENSG00000038358ENST00000577105I3L2F4

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Gene ExpressionREACTOMER-HSA-74160
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
mRNA decay by 5' to 3' exoribonucleaseREACTOMER-HSA-430039

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
245101892014The activation of the decapping enzyme DCP2 by DCP1 occurs on the EDC4 scaffold and involves a conserved loop in DCP1.33
295112132018Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1.9
247559892014LMKB/MARF1 localizes to mRNA processing bodies, interacts with Ge-1, and regulates IFI44L gene expression.8
229828642012EDC4 interacts with and regulates the dephospho-CoA kinase activity of CoA synthase.5
248585632014CCHCR1 interacts with EDC4, suggesting its localization in P-bodies.3
259703282015The Assembly of EDC4 and Dcp1a into Processing Bodies Is Critical for the Translational Regulation of IL-6.2

Citation

Dessen P

EDC4 (enhancer of mRNA decapping 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/62724/edc4-(enhancer-of-mrna-decapping-4)