GLRA3 (glycine receptor alpha 3)

2014-11-01  

Identity

HGNC
GLRA3
LOCATION
4q34.1
LOCUSID
8001
ALIAS
-

Other Information

Locus ID:

NCBI: 8001
MIM: 600421
HGNC: 4328
Ensembl: ENSG00000145451

Variants:

dbSNP: 8001
ClinVar: 8001
TCGA: ENSG00000145451
COSMIC: GLRA3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145451ENST00000274093O75311
ENSG00000145451ENST00000340217O75311

Expression (GTEx)

0
1
2
3
4
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Ligand-gated ion channel transportREACTOMER-HSA-975298

References

Pubmed IDYearTitleCitations
299475142018Identification of Novel Functionally Important Aromatic Residue Interactions in the Extracellular Domain of the Glycine Receptor.3
301203002018Confirmation of GLRA3 as a susceptibility locus for albuminuria in Finnish patients with type 1 diabetes.9
299475142018Identification of Novel Functionally Important Aromatic Residue Interactions in the Extracellular Domain of the Glycine Receptor.3
301203002018Confirmation of GLRA3 as a susceptibility locus for albuminuria in Finnish patients with type 1 diabetes.9
279919022017Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators.54
288834372017Alpha subunit-dependent glycine receptor clustering and regulation of synaptic receptor numbers.31
279919022017Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators.54
288834372017Alpha subunit-dependent glycine receptor clustering and regulation of synaptic receptor numbers.31
273820602016Electrophysiological Signature of Homomeric and Heteromeric Glycine Receptor Channels.9
273820602016Electrophysiological Signature of Homomeric and Heteromeric Glycine Receptor Channels.9
264167292015Crystal structure of human glycine receptor-α3 bound to antagonist strychnine.110
264167292015Crystal structure of human glycine receptor-α3 bound to antagonist strychnine.110
238345092013Phosphorylation of α3 glycine receptors induces a conformational change in the glycine-binding site.21
238345092013Phosphorylation of α3 glycine receptors induces a conformational change in the glycine-binding site.21
199594652010Multifunctional basic motif in the glycine receptor intracellular domain induces subunit-specific sorting.20

Citation

Dessen P

GLRA3 (glycine receptor alpha 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63826/css/lib/img/logo-atlas-4.svg