GRIA4 (glutamate ionotropic receptor AMPA type subunit 4)

2014-11-01  

Identity

HGNC
GRIA4
LOCATION
11q22.3
LOCUSID
2893
ALIAS
GLUR4,GLUR4C,GLURD,GluA4,NEDSGA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2893
MIM: 138246
HGNC: 4574
Ensembl: ENSG00000152578

Variants:

dbSNP: 2893
ClinVar: 2893
TCGA: ENSG00000152578
COSMIC: GRIA4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152578ENST00000282499P48058
ENSG00000152578ENST00000393125P48058
ENSG00000152578ENST00000393127G3V164
ENSG00000152578ENST00000428631P48058
ENSG00000152578ENST00000525187G3V164
ENSG00000152578ENST00000525921E9PJZ5
ENSG00000152578ENST00000525942H0YDL4
ENSG00000152578ENST00000527177E9PJZ5
ENSG00000152578ENST00000527669E9PR13
ENSG00000152578ENST00000530497P48058
ENSG00000152578ENST00000531011E9PQY1
ENSG00000152578ENST00000531986E9PJZ5

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
Retrograde endocannabinoid signalingKEGGhsa04723
Retrograde endocannabinoid signalingKEGGko04723
Amphetamine addictionKEGGhsa05031
Amphetamine addictionKEGGko05031
Nicotine addictionKEGGhsa05033
Nicotine addictionKEGGko05033
Circadian entrainmentKEGGhsa04713
Circadian entrainmentKEGGko04713
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314
Glutamate Binding, Activation of AMPA Receptors and Synaptic PlasticityREACTOMER-HSA-399721
Trafficking of AMPA receptorsREACTOMER-HSA-399719
Trafficking of GluR2-containing AMPA receptorsREACTOMER-HSA-416993
Activation of AMPA receptorsREACTOMER-HSA-399710
Activation of NMDA receptor upon glutamate binding and postsynaptic eventsREACTOMER-HSA-442755
Unblocking of NMDA receptor, glutamate binding and activationREACTOMER-HSA-438066
SALM protein interactions at the synapsesREACTOMER-HSA-8849932
Protein-protein interactions at synapsesREACTOMER-HSA-6794362

References

Pubmed IDYearTitleCitations
380032932023Association of SLC12A1 and GLUR4 Ion Transporters with Neoadjuvant Chemoresistance in Luminal Locally Advanced Breast Cancer.0
380032932023Association of SLC12A1 and GLUR4 Ion Transporters with Neoadjuvant Chemoresistance in Luminal Locally Advanced Breast Cancer.0
347190062022Colorectal cancer promoter methylation alteration affects the expression of glutamate ionotropic receptor AMPA type subunit 4 alternative isoforms potentially relevant in colon tissue.7
347190062022Colorectal cancer promoter methylation alteration affects the expression of glutamate ionotropic receptor AMPA type subunit 4 alternative isoforms potentially relevant in colon tissue.7
302878062018Genome-wide association study identifies glutamate ionotropic receptor GRIA4 as a risk gene for comorbid nicotine dependence and major depression.9
302878062018Genome-wide association study identifies glutamate ionotropic receptor GRIA4 as a risk gene for comorbid nicotine dependence and major depression.9
292206732017De Novo Variants in GRIA4 Lead to Intellectual Disability with or without Seizures and Gait Abnormalities.38
292206732017De Novo Variants in GRIA4 Lead to Intellectual Disability with or without Seizures and Gait Abnormalities.38
267441922016Superactivation of AMPA receptors by auxiliary proteins.25
274437842016Ionotropic glutamate receptor expression in human white matter.9
267441922016Superactivation of AMPA receptors by auxiliary proteins.25
274437842016Ionotropic glutamate receptor expression in human white matter.9
254339042015Altered glutamate protein co-expression network topology linked to spine loss in the auditory cortex of schizophrenia.38
254339042015Altered glutamate protein co-expression network topology linked to spine loss in the auditory cortex of schizophrenia.38
242921022014Changes of several brain receptor complexes in the cerebral cortex of patients with Alzheimer disease: probable new potential pharmaceutical targets.1

Citation

Dessen P

GRIA4 (glutamate ionotropic receptor AMPA type subunit 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64035/haematological-explorer/js/web-card-_common.js