HTR3E (5-hydroxytryptamine receptor 3E)

2014-11-01  

Identity

HGNC
HTR3E
LOCATION
3q27.1
LOCUSID
285242
ALIAS
5-HT3-E,5-HT3E,5-HT3c1

Other Information

Locus ID:

NCBI: 285242
MIM: 610123
HGNC: 24005
Ensembl: ENSG00000186038

Variants:

dbSNP: 285242
ClinVar: 285242
TCGA: ENSG00000186038
COSMIC: HTR3E

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000186038ENST00000335304A5X5Y0
ENSG00000186038ENST00000415389A5X5Y0
ENSG00000186038ENST00000425359A5X5Y0
ENSG00000186038ENST00000431041C9J420
ENSG00000186038ENST00000436361A5X5Y0
ENSG00000186038ENST00000440596A5X5Y0

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Taste transductionKEGGko04742
Taste transductionKEGGhsa04742
Serotonergic synapseKEGGhsa04726
Transmembrane transport of small moleculesREACTOMER-HSA-382551
Ion channel transportREACTOMER-HSA-983712
Ligand-gated ion channel transportREACTOMER-HSA-975298

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA449841haloperidolChemicalMultilinkAnnotationassociated27023437

References

Pubmed IDYearTitleCitations
2392829420145-HT3 receptor influences the washing phenotype and visual organization in obsessive-compulsive disorder supporting 5-HT3 receptor antagonists as novel treatment option.8
2392829420145-HT3 receptor influences the washing phenotype and visual organization in obsessive-compulsive disorder supporting 5-HT3 receptor antagonists as novel treatment option.8
211920762011Serotonin receptor diversity in the human colon: Expression of serotonin type 3 receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E.23
211920762011Serotonin receptor diversity in the human colon: Expression of serotonin type 3 receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E.23
200212652010Two naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancy.7
203567182010A coding variant of the novel serotonin receptor subunit 5-HT3E influences sustained attention in schizophrenia patients.8
203567182010A coding variant of the novel serotonin receptor subunit 5-HT3E influences sustained attention in schizophrenia patients.8
205389602010A candidate gene study of obstructive sleep apnea in European Americans and African Americans.43
206026132010Polymorphism in HTR3D shows different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy.10
200212652010Two naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancy.7
203567182010A coding variant of the novel serotonin receptor subunit 5-HT3E influences sustained attention in schizophrenia patients.8
203567182010A coding variant of the novel serotonin receptor subunit 5-HT3E influences sustained attention in schizophrenia patients.8
205389602010A candidate gene study of obstructive sleep apnea in European Americans and African Americans.43
206026132010Polymorphism in HTR3D shows different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy.10
185732762009Central 5-HT receptors in cardiovascular control during stress.15

Citation

Dessen P

HTR3E (5-hydroxytryptamine receptor 3E)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64471/favicon/tumors-explorer/css/card-gene.css