HYPK (huntingtin interacting protein K)

2014-11-01  

Identity

HGNC
HYPK
LOCATION
15q15.3
LOCUSID
25764
ALIAS
C15orf63,HSPC136
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 25764
MIM: 612784
HGNC: 18418
Ensembl: ENSG00000242028

Variants:

dbSNP: 25764
ClinVar: 25764
TCGA: ENSG00000242028
COSMIC: HYPK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000242028ENST00000406925Q9NX55
ENSG00000242028ENST00000442995Q9NX55
ENSG00000242028ENST00000458412J3QT56

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
179472972008HYPK, a Huntingtin interacting protein, reduces aggregates and apoptosis induced by N-terminal Huntingtin with 40 glutamines in Neuro2a cells and exhibits chaperone-like activity.22
285855742017Structural basis of HypK regulating N-terminal acetylation by the NatA complex.11
297548252018Structure of Human NatA and Its Regulation by the Huntingtin Interacting Protein HYPK.10
232721042012Identification of HYPK-interacting proteins reveals involvement of HYPK in regulating cell growth, cell cycle, unfolded protein response and cell death.8
254460992015Chaperone protein HYPK interacts with the first 17 amino acid region of Huntingtin and modulates mutant HTT-mediated aggregation and cytotoxicity.8
244655982014Transcription regulation of HYPK by Heat Shock Factor 1.5
270179302016Huntingtin interacting protein HYPK is a negative regulator of heat shock response and is downregulated in models of Huntington's Disease.5
243616042014Heat shock transcription factor HSF1 regulates the expression of the Huntingtin-interacting protein HYPK.4
251166202014Conserved C-terminal nascent peptide binding domain of HYPK facilitates its chaperone-like activity.4
293813482018Disordered Nanostructure in Huntingtin Interacting Protein K Acts as a Stabilizing Switch To Prevent Protein Aggregation.2

Citation

Dessen P

HYPK (huntingtin interacting protein K)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64482/hypk