IDH3G (isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma)

2014-11-01  

Identity

HGNC
LOCATION
Xq28
LOCUSID
ALIAS
H-IDHG
FUSION GENES

Other Information

Locus ID:

NCBI: 3421
MIM: 300089
HGNC: 5386
Ensembl: ENSG00000067829

Variants:

dbSNP: 3421
ClinVar: 3421
TCGA: ENSG00000067829
COSMIC: IDH3G

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000067829ENST00000217901P51553
ENSG00000067829ENST00000370092P51553
ENSG00000067829ENST00000370093E7EQB8
ENSG00000067829ENST00000427365G5E9Q7
ENSG00000067829ENST00000444338H7C1W2
ENSG00000067829ENST00000444450E9PF84
ENSG00000067829ENST00000454076H0Y5Q7
ENSG00000067829ENST00000619865G5E9Q7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
Citrate cycle (TCA cycle)KEGGko00020
Citrate cycle (TCA cycle)KEGGhsa00020
Metabolic pathwaysKEGGhsa01100
Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarateKEGGhsa_M00010
Citrate cycle (TCA cycle, Krebs cycle)KEGGM00009
Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarateKEGGM00010
2-Oxocarboxylic acid metabolismKEGGhsa01210
2-Oxocarboxylic acid metabolismKEGGko01210
Biosynthesis of amino acidsKEGGhsa01230
Biosynthesis of amino acidsKEGGko01230
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200
Citrate cycle (TCA cycle, Krebs cycle)KEGGhsa_M00009
Metabolism of proteinsREACTOMER-HSA-392499
Mitochondrial protein importREACTOMER-HSA-1268020
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Pyruvate metabolism and Citric Acid (TCA) cycleREACTOMER-HSA-71406
Citric acid cycle (TCA cycle)REACTOMER-HSA-71403

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
174328782007Role of alpha-Asp181, beta-Asp192, and gamma-Asp190 in the distinctive subunits of human NAD-specific isocitrate dehydrogenase.17
174328782007Role of alpha-Asp181, beta-Asp192, and gamma-Asp190 in the distinctive subunits of human NAD-specific isocitrate dehydrogenase.17
167379552006Identification of Mn2+-binding aspartates from alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase.15
167379552006Identification of Mn2+-binding aspartates from alpha, beta, and gamma subunits of human NAD-dependent isocitrate dehydrogenase.15

Citation

Dessen P

IDH3G (isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64496/img/case-report-explorer/js/web-card-gene.js