IGHG2 (immunoglobulin heavy constant gamma 2 (G2m marker))

2014-11-01 Affiliation

Identity

HGNC

IGHG2

LOCATION

14q32.33

LOCUSID

3501

ALIAS

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3501
MIM: 147110
HGNC: 5526
Ensembl: ENSG00000211893
IMGT/GENE-DB:

Variants:

dbSNP: 3501
ClinVar: 3501
TCGA: ENSG00000211893
COSMIC: IGHG2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000211893	ENST00000390545	P01859
ENSG00000211893	ENST00000641095	A0A286YEY4

Expression (GTEx)

500

1000

1500

2000

2500

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Complement cascade	REACTOME	R-HSA-166658
Initial triggering of complement	REACTOME	R-HSA-166663
Creation of C4 and C2 activators	REACTOME	R-HSA-166786
Classical antibody-mediated complement activation	REACTOME	R-HSA-173623
Fcgamma receptor (FCGR) dependent phagocytosis	REACTOME	R-HSA-2029480
FCGR activation	REACTOME	R-HSA-2029481
Regulation of actin dynamics for phagocytic cup formation	REACTOME	R-HSA-2029482
Role of phospholipids in phagocytosis	REACTOME	R-HSA-2029485

References

Pubmed ID	Year	Title	Citations
18974198	2009	The effect of Fc glycan forms on human IgG2 antibody clearance in humans.	29
18821675	2008	Immunoglobulin gene polymorphisms are susceptibility factors in clinical and autoantibody subgroups of the idiopathic inflammatory myopathies.	13
16785571	2006	Homozygosity for the IgG2 subclass allotype G2M(n) protects against severe infection in hereditary C2 deficiency.	10
16944158	2007	Immunoglobulin GM and KM genotypes in Korean patients with systemic lupus erythematosus.	2
25842870	2014	[[correlation between macro- and micro-stability C(H)2 domains of human IgG2 and their biological activity. II. Calculation of thermodynamic functions characterizing domains stability].	0

Citation

Dessen P

IGHG2 (immunoglobulin heavy constant gamma 2 (G2m marker))

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64548/ighg2