JCHAIN (joining chain of multimeric IgA and IgM)

2014-11-01  

Identity

HGNC
JCHAIN
LOCATION
4q13.3
LOCUSID
3512
ALIAS
IGCJ,IGJ,JCH
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3512
MIM: 147790
HGNC: 5713
Ensembl: ENSG00000132465

Variants:

dbSNP: 3512
ClinVar: 3512
TCGA: ENSG00000132465
COSMIC: JCHAIN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132465ENST00000254801P01591
ENSG00000132465ENST00000391614D6RHJ6
ENSG00000132465ENST00000470866C9JA05
ENSG00000132465ENST00000510437P01591
ENSG00000132465ENST00000510614D6RD17
ENSG00000132465ENST00000543780P01591

Expression (GTEx)

0
500
1000
1500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Vesicle-mediated transportREACTOMER-HSA-5653656
Binding and Uptake of Ligands by Scavenger ReceptorsREACTOMER-HSA-2173782
Scavenging of heme from plasmaREACTOMER-HSA-2168880

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
375397062023IGJ suppresses breast cancer growth and metastasis by inhibiting EMT via the NF‑κB signaling pathway.0
375397062023IGJ suppresses breast cancer growth and metastasis by inhibiting EMT via the NF‑κB signaling pathway.0
270445432016High expression of ID family and IGJ genes signature as predictor of low induction treatment response and worst survival in adult Hispanic patients with B-acute lymphoblastic leukemia.13
270445432016High expression of ID family and IGJ genes signature as predictor of low induction treatment response and worst survival in adult Hispanic patients with B-acute lymphoblastic leukemia.13
209474332011Toll-like receptor 2 induces mucosal homing receptor expression and IgA production by human B cells.18
209474332011Toll-like receptor 2 induces mucosal homing receptor expression and IgA production by human B cells.18
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.37
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.37

Citation

Dessen P

JCHAIN (joining chain of multimeric IgA and IgM)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64558/haematological-explorer/js/lib/js/lib/all.min.js