IL22RA2 (interleukin 22 receptor subunit alpha 2)

2014-11-01  

Identity

HGNC
IL22RA2
LOCATION
6q23.3
LOCUSID
116379
ALIAS
CRF2-10,CRF2-S1,CRF2X,IL-22BP,IL-22R-alpha-2,IL-22RA2,ZCYTOR16
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 116379
MIM: 606648
HGNC: 14901
Ensembl: ENSG00000164485

Variants:

dbSNP: 116379
ClinVar: 116379
TCGA: ENSG00000164485
COSMIC: IL22RA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164485ENST00000296980Q969J5
ENSG00000164485ENST00000339602Q969J5
ENSG00000164485ENST00000349184Q969J5

Expression (GTEx)

0
1
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-19, 20, 22, 24REACTOMER-HSA-8854691

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
379759162023Circulating apelin, IL22RA2 and VEGF in pre-capillary pulmonary hypertension.0
379759162023Circulating apelin, IL22RA2 and VEGF in pre-capillary pulmonary hypertension.0
349202292022Liver expression of IL-22, IL-22R1 and IL-22BP in patients with chronic hepatitis C with different fibrosis stages.1
361089912022Down-regulating Interleukin-22/Interleukin-22 binding protein axis promotes inflammation and aggravates diet-induced metabolic disorders.3
363117962022IL-22BP production is heterogeneously distributed in Crohn's disease.1
349202292022Liver expression of IL-22, IL-22R1 and IL-22BP in patients with chronic hepatitis C with different fibrosis stages.1
361089912022Down-regulating Interleukin-22/Interleukin-22 binding protein axis promotes inflammation and aggravates diet-induced metabolic disorders.3
363117962022IL-22BP production is heterogeneously distributed in Crohn's disease.1
338512572021The good and the bad about separation anxiety: roles of IL-22 and IL-22BP in liver pathologies.11
338512572021The good and the bad about separation anxiety: roles of IL-22 and IL-22BP in liver pathologies.11
319367652020The Rare IL22RA2 Signal Peptide Coding Variant rs28385692 Decreases Secretion of IL-22BP Isoform-1, -2 and -3 and Is Associated with Risk for Multiple Sclerosis.0
326325452020Elevated IL-22 in psoriasis plays an anti-apoptotic role in keratinocytes through mediating Bcl-xL/Bax.0
329552032020Low Interleukin-22 Binding Protein Is Associated With High Mortality in Alcoholic Hepatitis and Modulates Interleukin-22 Receptor Expression.5
319367652020The Rare IL22RA2 Signal Peptide Coding Variant rs28385692 Decreases Secretion of IL-22BP Isoform-1, -2 and -3 and Is Associated with Risk for Multiple Sclerosis.0
326325452020Elevated IL-22 in psoriasis plays an anti-apoptotic role in keratinocytes through mediating Bcl-xL/Bax.0

Citation

Dessen P

IL22RA2 (interleukin 22 receptor subunit alpha 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64597/css/lib/js/lib/zoomerang.js