KCNAB2 (potassium voltage-gated channel subfamily A regulatory beta subunit 2)

2014-11-01  

Identity

HGNC
KCNAB2
LOCATION
1p36.31
LOCUSID
8514
ALIAS
AKR6A5,HKvbeta2,HKvbeta2.1,HKvbeta2.2,KCNA2B,KV-BETA-2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8514
MIM: 601142
HGNC: 6229
Ensembl: ENSG00000069424

Variants:

dbSNP: 8514
ClinVar: 8514
TCGA: ENSG00000069424
COSMIC: KCNAB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000069424ENST00000164247Q13303
ENSG00000069424ENST00000164247A0A024R4E3
ENSG00000069424ENST00000352527Q13303
ENSG00000069424ENST00000378083Q13303
ENSG00000069424ENST00000378092Q13303
ENSG00000069424ENST00000378092A0A024R4E3
ENSG00000069424ENST00000378097Q13303
ENSG00000069424ENST00000378097A0A024R4E3
ENSG00000069424ENST00000378111Q5TG84
ENSG00000069424ENST00000389632Q5TG81
ENSG00000069424ENST00000428161Q13303
ENSG00000069424ENST00000428161A0A024R4E3
ENSG00000069424ENST00000428161Q5TG80
ENSG00000069424ENST00000445501Q5TG78
ENSG00000069424ENST00000458166Q13303
ENSG00000069424ENST00000462676K7EKU4
ENSG00000069424ENST00000472700K7EIR5
ENSG00000069424ENST00000602612Q13303
ENSG00000069424ENST00000652845A0A590UJX9
ENSG00000069424ENST00000653262A0A590UJJ4
ENSG00000069424ENST00000655548A0A590UJY1
ENSG00000069424ENST00000655703A0A590UJ15
ENSG00000069424ENST00000656198A0A590UJU4
ENSG00000069424ENST00000656746A0A590UJK5
ENSG00000069424ENST00000658691A0A590UJI8
ENSG00000069424ENST00000658883A0A590UJ72
ENSG00000069424ENST00000662147A0A590UJB8
ENSG00000069424ENST00000662363A0A590UJB6
ENSG00000069424ENST00000662815A0A590UJ35
ENSG00000069424ENST00000663169A0A590UK89
ENSG00000069424ENST00000666163Q13303
ENSG00000069424ENST00000666299A0A590UJV4
ENSG00000069424ENST00000668559Q13303
ENSG00000069424ENST00000668706A0A590UJU1
ENSG00000069424ENST00000669250Q13303
ENSG00000069424ENST00000671076A0A590UJ79
ENSG00000069424ENST00000671676Q13303
ENSG00000069424ENST00000671676A0A024R4E3

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuronal SystemREACTOMER-HSA-112316
Potassium ChannelsREACTOMER-HSA-1296071
Voltage gated Potassium channelsREACTOMER-HSA-1296072
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
232645832013Genetic variation in KCNA5: impact on the atrial-specific potassium current IKur in patients with lone atrial fibrillation.41
272876952016Dysfunction of the Voltage-Gated K+ Channel β2 Subunit in a Familial Case of Brugada Syndrome.10
233909572013Incretin-stimulated interaction between β-cell Kv1.5 and Kvβ2 channel proteins involves acetylation/deacetylation by CBP/SirT1.6

Citation

Dessen P

KCNAB2 (potassium voltage-gated channel subfamily A regulatory beta subunit 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64762/kcnab2