KLC4 (kinesin light chain 4)

2014-11-01  

Identity

HGNC
KLC4
LOCATION
6p21.1
LOCUSID
89953
ALIAS
KNSL8,bA387M24.3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 89953
HGNC: 21624
Ensembl: ENSG00000137171

Variants:

dbSNP: 89953
ClinVar: 89953
TCGA: ENSG00000137171
COSMIC: KLC4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137171ENST00000259708Q9NSK0
ENSG00000137171ENST00000347162Q9NSK0
ENSG00000137171ENST00000347162A0A024RCZ8
ENSG00000137171ENST00000394056Q9NSK0
ENSG00000137171ENST00000394056A0A024RCZ8
ENSG00000137171ENST00000453940Q9NSK0
ENSG00000137171ENST00000458460Q9NSK0
ENSG00000137171ENST00000460283C9JQU1
ENSG00000137171ENST00000467906Q9NSK0
ENSG00000137171ENST00000469987H7C4M1
ENSG00000137171ENST00000470728C9J8T5
ENSG00000137171ENST00000472792C9JXT5
ENSG00000137171ENST00000479388Q9NSK0
ENSG00000137171ENST00000479388A0A024RCZ8
ENSG00000137171ENST00000479632C9JZE5
ENSG00000137171ENST00000481499F8WCA4
ENSG00000137171ENST00000481888C9K0D5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Salmonella infectionKEGGko05132
Salmonella infectionKEGGhsa05132
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
MHC class II antigen presentationREACTOMER-HSA-2132295
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
KinesinsREACTOMER-HSA-983189
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases activate KTN1REACTOMER-HSA-5625970
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Golgi-to-ER retrograde transportREACTOMER-HSA-8856688
COPI-dependent Golgi-to-ER retrograde trafficREACTOMER-HSA-6811434

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
324574232020Kinesin light chain 4 as a new target for lung cancer chemoresistance via targeted inhibition of checkpoint kinases in the DNA repair network.4
324574232020Kinesin light chain 4 as a new target for lung cancer chemoresistance via targeted inhibition of checkpoint kinases in the DNA repair network.4
312352512019SETD3 reduces KLC4 expression to improve the sensitization of cervical cancer cell to radiotherapy.5
312352512019SETD3 reduces KLC4 expression to improve the sensitization of cervical cancer cell to radiotherapy.5
264239252015Hereditary spastic paraplegia with recessive trait caused by mutation in KLC4 gene.8
264239252015Hereditary spastic paraplegia with recessive trait caused by mutation in KLC4 gene.8
208183312010Insight into the molecular mechanism of the multitasking kinesin-8 motor.37
208183312010Insight into the molecular mechanism of the multitasking kinesin-8 motor.37

Citation

Dessen P

KLC4 (kinesin light chain 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64945/js/lib/css/card-gene.css