DDX6 (DEAD-box helicase 6)

2003-02-01  

Identity

HGNC
DDX6
LOCATION
11q23.3
LOCUSID
1656
ALIAS
HLR2,IDDILF,P54,RCK,Rck/p54
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1656
MIM: 600326
HGNC: 2747
Ensembl: ENSG00000110367

Variants:

dbSNP: 1656
ClinVar: 1656
TCGA: ENSG00000110367
COSMIC: DDX6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000110367ENST00000526070P26196
ENSG00000110367ENST00000534980P26196
ENSG00000110367ENST00000617381Q8IV96
ENSG00000110367ENST00000620157P26196

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
RNA degradationKEGGko03018
RNA degradationKEGGhsa03018
Decapping complexKEGGhsa_M00395
Decapping complexKEGGM00395
Gene ExpressionREACTOMER-HSA-74160
Deadenylation-dependent mRNA decayREACTOMER-HSA-429914
mRNA decay by 5' to 3' exoribonucleaseREACTOMER-HSA-430039

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383779442024DDX6 is involved in the pathogenesis of inflammatory diseases via NF-κB activation.0
385360352024DDX6 modulates P-body and stress granule assembly, composition, and docking.0
385516422024The DDX6/KIFC1 signaling axis, as regulated by YY1, contributes to the malignant behavior of pancreatic cancer.0
388349472024Rab3B enhances the stabilization of DDX6 to promote lung adenocarcinoma aggressiveness.0
383779442024DDX6 is involved in the pathogenesis of inflammatory diseases via NF-κB activation.0
385360352024DDX6 modulates P-body and stress granule assembly, composition, and docking.0
385516422024The DDX6/KIFC1 signaling axis, as regulated by YY1, contributes to the malignant behavior of pancreatic cancer.0
388349472024Rab3B enhances the stabilization of DDX6 to promote lung adenocarcinoma aggressiveness.0
363228272023miR-148a-3p and DDX6 functional link promotes survival of myeloid leukemia cells.2
368346092023RNA Helicase DDX6 Regulates A-to-I Editing and Neuronal Differentiation in Human Cells.3
374277912023RNA helicase DDX6 and scaffold protein GW182 in P-bodies promote biogenesis of stress granules.6
363228272023miR-148a-3p and DDX6 functional link promotes survival of myeloid leukemia cells.2
368346092023RNA Helicase DDX6 Regulates A-to-I Editing and Neuronal Differentiation in Human Cells.3
374277912023RNA helicase DDX6 and scaffold protein GW182 in P-bodies promote biogenesis of stress granules.6
359744452022Circulating Exosomal circRNA_0063476 Impairs Expression of Markers of Bone Growth Via the miR-518c-3p/DDX6 Axis in ISS.1

Citation

Dessen P

DDX6 (DEAD-box helicase 6)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/65/deep-insight-explorer/case-report-explorer/js/template.js