ANTXR1 (ANTXR cell adhesion molecule 1)

2003-06-01 Affiliation

Identity

HGNC

ANTXR1

LOCATION

2p13.3

LOCUSID

84168

ALIAS

ATR,GAPO,TEM8

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 84168
MIM: 606410
HGNC: 21014
Ensembl: ENSG00000169604

Variants:

dbSNP: 84168
ClinVar: 84168
TCGA: ENSG00000169604
COSMIC: ANTXR1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000169604	ENST00000303714	Q9H6X2
ENSG00000169604	ENST00000409349	Q9H6X2
ENSG00000169604	ENST00000409829	Q9H6X2
ENSG00000169604	ENST00000482235	H0YC24

Expression (GTEx)

100

150

200

250

300

350

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
NOD-like receptor signaling pathway	KEGG	ko04621
NOD-like receptor signaling pathway	KEGG	hsa04621
Disease	REACTOME	R-HSA-1643685
Infectious disease	REACTOME	R-HSA-5663205
Uptake and actions of bacterial toxins	REACTOME	R-HSA-5339562
Uptake and function of anthrax toxins	REACTOME	R-HSA-5210891

References

Pubmed ID	Year	Title	Citations
11700562	2001	Identification of the cellular receptor for anthrax toxin.	361
16401723	2006	Receptor palmitoylation and ubiquitination regulate anthrax toxin endocytosis.	86
16141341	2005	Receptor-specific requirements for anthrax toxin delivery into cells.	68
22340594	2012	TEM8/ANTXR1 blockade inhibits pathological angiogenesis and potentiates tumoricidal responses against multiple cancer types.	59
15777794	2005	TEM8 expression stimulates endothelial cell adhesion and migration by regulating cell-matrix interactions on collagen.	55
20221438	2010	Endocytosis of the anthrax toxin is mediated by clathrin, actin and unconventional adaptors.	50
15689409	2005	ATR/TEM8 is highly expressed in epithelial cells lining Bacillus anthracis' three sites of entry: implications for the pathogenesis of anthrax infection.	46
15689409	2005	ATR/TEM8 is highly expressed in epithelial cells lining Bacillus anthracis' three sites of entry: implications for the pathogenesis of anthrax infection.	46
16762926	2006	Anthrax toxin receptor 1/tumor endothelium marker 8 mediates cell spreading by coupling extracellular ligands to the actin cytoskeleton.	43
23832666	2013	ANTXR1, a stem cell-enriched functional biomarker, connects collagen signaling to cancer stem-like cells and metastasis in breast cancer.	41

Citation

Dessen P

ANTXR1 (ANTXR cell adhesion molecule 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/652/antxr1-(antxr-cell-adhesion-molecule-1)