LILRB3 (leukocyte immunoglobulin like receptor B3)

2014-11-01 Affiliation

Identity

HGNC

LILRB3

LOCATION

19q13.42

LOCUSID

11025

ALIAS

CD85A,HL9,ILT-5,ILT5,LILRA6,LIR-3,LIR3,PIR-B,PIRB

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 11025
MIM: 604820
HGNC: 6607
Ensembl: ENSG00000204577

Variants:

dbSNP: 11025
ClinVar: 11025
TCGA: ENSG00000204577
COSMIC: LILRB3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000204577	ENST00000245620	O75022
ENSG00000204577	ENST00000346401	F8W6G6
ENSG00000204577	ENST00000391750	O75022
ENSG00000204577	ENST00000414379	F8WD89
ENSG00000204577	ENST00000445347	C9JWL8

Expression (GTEx)

100

150

200

250

300

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
B cell receptor signaling pathway	KEGG	ko04662
B cell receptor signaling pathway	KEGG	hsa04662
Osteoclast differentiation	KEGG	ko04380
Osteoclast differentiation	KEGG	hsa04380
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	REACTOME	R-HSA-198933
Innate Immune System	REACTOME	R-HSA-168249
Neutrophil degranulation	REACTOME	R-HSA-6798695

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
20631139	2010	Leukocyte immunoglobulin-like receptors maintain unique antigen-presenting properties of circulating myeloid dendritic cells in HIV-1-infected elite controllers.	35
18802077	2008	Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development.	32
15242876	2004	Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition.	20
25604533	2015	Identification of Susceptibility Loci in IL6, RPS9/LILRB3, and an Intergenic Locus on Chromosome 21q22 in Takayasu Arteritis in a Genome-Wide Association Study.	18
17998301	2008	Differential expression of leukocyte immunoglobulin-like receptors on cord-blood-derived human mast cell progenitors and mature mast cells.	13
20628086	2010	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.	11
30068593	2018	Glatiramer Acetate Enhances Myeloid-Derived Suppressor Cell Function via Recognition of Paired Ig-like Receptor B.	1
31250008	2019	Immunoglobulin-Like Transcript 5 Inhibits Macrophage-Mediated Bacterial Killing and Antigen Presentation During Sepsis.	0

Citation

Dessen P

LILRB3 (leukocyte immunoglobulin like receptor B3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/65265/lilrb3