TCL1A (T-cell leukemia/lymphoma 1A)

1998-03-01   Marc-Henri Stern 

Unité INSERM U462, Centre Hayem, Hopital Saint Louis, 75475 Paris Cedex 10, France

Identity

HGNC
TCL1A
LOCATION
14q32.13
LOCUSID
8115
ALIAS
TCL1
FUSION GENES
Show Gene Fusions

DNA/RNA

Description

4 exons; telomere - exon 1 to 4 - centromere orientation

Transcription

1.3 kb transcripts

Proteins

Description

114 amino acids; one domain with a b-barrel topology

Expression

immature T and B lymphoid cells

Localisation

cytoplasm

Function

unknown

Homology

MTCP1 (38 % identity, similar tridimentional structure)

Implicated in

Entity name
t(14;14)(q12;q32.1) or inv(14)(q12q32.1) /T-cell malignancies --> TCRA/D - TCL1A
Disease
mainly T-cell prolymphocytic leukemia (T-PLL); T- cell NHL; T-cell ALL
Cytogenetics
associated with i(8q) in T-PLL
Hybrid gene
none
Fusion protein
none
Oncogenesis
over expression of TCL1 is considered as critical in the oncogenetic mechanism
Entity name
t(7;14)(q35;q32.1)/T-cell malignancies --> TCRB - TCL1A
Disease
mainly T-cell prolymphocytic leukemia
Cytogenetics
associated with i(8q)
Hybrid gene
none
Fusion protein
none
Oncogenesis
over expression of TCL1

Bibliography

Pubmed IDLast YearTitleAuthors
79878161994Characterization and localization of the TCL-1 oncogene product.Fu TB et al
95194061998Crystal structure of p14TCL1, an oncogene product involved in T-cell prolymphocytic leukemia, reveals a novel beta-barrel topology.Hoh F et al
92856871997The murine Tcl1 oncogene: embryonic and lymphoid cell expression.Narducci MG et al
85702151996Expression of either the TCL1 oncogene, or transcripts from its homologue MTCP1/c6.1B, in leukaemic and non-leukaemic T cells from ataxia telangiectasia patients.Thick J et al
78090721994Identification of the TCL1 gene involved in T-cell malignancies.Virgilio L et al

Other Information

Locus ID:

NCBI: 8115
MIM: 186960
HGNC: 11648
Ensembl: ENSG00000100721

Variants:

dbSNP: 8115
ClinVar: 8115
TCGA: ENSG00000100721
COSMIC: TCL1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100721ENST00000402399P56279
ENSG00000100721ENST00000402399A0A024R6G5
ENSG00000100721ENST00000554012P56279
ENSG00000100721ENST00000554012A0A024R6G5
ENSG00000100721ENST00000554119G3V4T4
ENSG00000100721ENST00000555202P56279
ENSG00000100721ENST00000555202A0A024R6G5
ENSG00000100721ENST00000555886G3V4T4
ENSG00000100721ENST00000556156G3V4T4
ENSG00000100721ENST00000556450P56279
ENSG00000100721ENST00000556450A0A024R6G5
ENSG00000100721ENST00000557043H0YJR9

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
171788512006Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181.218
208764202010Genome-wide associations and functional genomic studies of musculoskeletal adverse events in women receiving aromatase inhibitors.86
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
190649212008Tcl1 functions as a transcriptional regulator and is directly involved in the pathogenesis of CLL.41
123817892002Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma.30
224051312012Aromatase inhibitors, estrogens and musculoskeletal pain: estrogen-dependent T-cell leukemia 1A (TCL1A) gene-mediated regulation of cytokine expression.29
125763132003TCL1 expression in plasmacytoid dendritic cells (DC2s) and the related CD4+ CD56+ blastic tumors of skin.25
154592052004Inhibition of Akt kinase activity by a peptide spanning the betaA strand of the proto-oncogene TCL1.23
256464132015TCL1 targeting miR-3676 is codeleted with tumor protein p53 in chronic lymphocytic leukemia.23
173608492007Proto-oncogene TCL1: more than just a coactivator for Akt.22

Citation

Marc-Henri Stern

TCL1A (T-cell leukemia/lymphoma 1A)

Atlas Genet Cytogenet Oncol Haematol. 1998-03-01

Online version: http://atlasgeneticsoncology.org/gene/66/tcl1a