APBB1 (amyloid beta precursor protein binding family B member 1)

2003-06-01  

Identity

HGNC
LOCATION
11p15.4
LOCUSID
ALIAS
FE65,MGC:9072,RIR
FUSION GENES

Other Information

Locus ID:

NCBI: 322
MIM: 602709
HGNC: 581
Ensembl: ENSG00000166313

Variants:

dbSNP: 322
ClinVar: 322
TCGA: ENSG00000166313
COSMIC: APBB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166313ENST00000299402O00213
ENSG00000166313ENST00000311051O00213
ENSG00000166313ENST00000389906J3KPL8
ENSG00000166313ENST00000529519V9GYR7
ENSG00000166313ENST00000529890V9GY97
ENSG00000166313ENST00000530885O00213
ENSG00000166313ENST00000532020V9GYD5
ENSG00000166313ENST00000608394O00213
ENSG00000166313ENST00000608435A0A075B7G8
ENSG00000166313ENST00000608645O00213
ENSG00000166313ENST00000608655O00213
ENSG00000166313ENST00000608704O00213
ENSG00000166313ENST00000609331O00213
ENSG00000166313ENST00000609360O00213
ENSG00000166313ENST00000610474A0A087X0V7
ENSG00000166313ENST00000618005A0A087X0V7
ENSG00000166313ENST00000621678A0A087WYH9

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
Alzheimer's diseaseKEGGko05010
Alzheimer's diseaseKEGGhsa05010
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
DNA Double Strand Break ResponseREACTOMER-HSA-5693606
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksREACTOMER-HSA-5693565

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
379185522023Alpha-secretase dependent nuclear localization of the amyloid-β precursor protein-binding protein Fe65 promotes DNA repair.0
379185522023Alpha-secretase dependent nuclear localization of the amyloid-β precursor protein-binding protein Fe65 promotes DNA repair.0
330473932020ARF6-Rac1 signaling-mediated neurite outgrowth is potentiated by the neuronal adaptor FE65 through orchestrating ARF6 and ELMO1.8
331239062020Aβ40 Promotes the Osteoblastic Differentiation of Aortic Valve Interstitial Cells through the RAGE Pathway.2
330473932020ARF6-Rac1 signaling-mediated neurite outgrowth is potentiated by the neuronal adaptor FE65 through orchestrating ARF6 and ELMO1.8
331239062020Aβ40 Promotes the Osteoblastic Differentiation of Aortic Valve Interstitial Cells through the RAGE Pathway.2
296154912018Neuronal adaptor FE65 stimulates Rac1-mediated neurite outgrowth by recruiting and activating ELMO1.13
296154912018Neuronal adaptor FE65 stimulates Rac1-mediated neurite outgrowth by recruiting and activating ELMO1.13
278365462017APBB1 reinforces cancer stem cell and epithelial-to-mesenchymal transition by regulating the IGF1R signaling pathway in non-small-cell lung cancer cells.9
283238442017Nuclear localization of amyloid-β precursor protein-binding protein Fe65 is dependent on regulated intramembrane proteolysis.5
289635162017Phosphorylation of FE65 at threonine 579 by GSK3β stimulates amyloid precursor protein processing.9
278365462017APBB1 reinforces cancer stem cell and epithelial-to-mesenchymal transition by regulating the IGF1R signaling pathway in non-small-cell lung cancer cells.9
283238442017Nuclear localization of amyloid-β precursor protein-binding protein Fe65 is dependent on regulated intramembrane proteolysis.5
289635162017Phosphorylation of FE65 at threonine 579 by GSK3β stimulates amyloid precursor protein processing.9
271760722016Fe65 Is Phosphorylated on Ser289 after UV-Induced DNA Damage.2

Citation

Dessen P

APBB1 (amyloid beta precursor protein binding family B member 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/665/haematological-explorer/tumors-explorer/css/lib/dataTables.bootstrap.min.css