ATG4A (autophagy related 4A cysteine peptidase)

2003-10-01  

Identity

HGNC
ATG4A
LOCATION
Xq22.3
LOCUSID
115201
ALIAS
APG4A,AUTL2

Other Information

Locus ID:

NCBI: 115201
MIM: 300663
HGNC: 16489
Ensembl: ENSG00000101844

Variants:

dbSNP: 115201
ClinVar: 115201
TCGA: ENSG00000101844
COSMIC: ATG4A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101844ENST00000343524G5E979
ENSG00000101844ENST00000345734Q8WYN0
ENSG00000101844ENST00000372232Q8WYN0
ENSG00000101844ENST00000372246F8W7J2
ENSG00000101844ENST00000394892H7BYM2
ENSG00000101844ENST00000457035A0A0A0MT61

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
Autophagy - otherKEGGko04136
Autophagy - otherKEGGhsa04136

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
173476512007Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4.707
211778652011Kinetics comparisons of mammalian Atg4 homologues indicate selective preferences toward diverse Atg8 substrates.74
242294642013A mammosphere formation RNAi screen reveals that ATG4A promotes a breast cancer stem-like phenotype.35
235080062013Autophagy facilitates organelle clearance during differentiation of human erythroblasts: evidence for a role for ATG4 paralogs during autophagosome maturation.33
124736582003The COOH terminus of GATE-16, an intra-Golgi transport modulator, is cleaved by the human cysteine protease HsApg4A.31
254265602015Mir-24-3p downregulation contributes to VP16-DDP resistance in small-cell lung cancer by targeting ATG4A.28
208197782010MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.21
242568132014Hypomethylation signature of tumor-initiating cells predicts poor prognosis of ovarian cancer patients.17
272766862016ATG4A promotes tumor metastasis by inducing the epithelial-mesenchymal transition and stem-like properties in gastric cells.8
306614292019Redundancy of human ATG4 protease isoforms in autophagy and LC3/GABARAP processing revealed in cells.8

Citation

Dessen P

ATG4A (autophagy related 4A cysteine peptidase)

Atlas Genet Cytogenet Oncol Haematol. 2003-10-01

Online version: http://atlasgeneticsoncology.org/gene/671/atg4a-(autophagy-related-4a-cysteine-peptidase)